Characterizing the fitness cost of viral escape from the HIV-1 broadly neutralizing monoclonal antibody VRC01

被引：0
|
作者：
Lynch, R. M. [1 ]
Tran, L. [1 ]
Wu, X. [1 ]
Li, Y. [2 ]
Lee, B. [3 ]
Mascola, J. [1 ]
机构：
[1] NIAID, NIH, Bethesda, MD 20892 USA
[2] Scripps Res Inst, La Jolla, CA 92037 USA
[3] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA
来源：
RETROVIROLOGY | 2012年 / 9卷
关键词：
Replication Kinetic; Viral Escape; Replicative Fitness; Infectious Molecular Clone; Antibody VRC01;
D O I：
10.1186/1742-4690-9-S2-P87
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Characterizing the fitness cost of viral escape from the HIV-1 broadly neutralizing monoclonal antibody VRC01
    RM Lynch
    L Tran
    X Wu
    Y Li
    B Lee
    J Mascola
    [J]. Retrovirology, 9
  • [2] Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01
    Li, Yuxing
    O'Dell, Sijy
    Walker, Laura M.
    Wu, Xueling
    Guenaga, Javier
    Feng, Yu
    Schmidt, Stephen D.
    McKee, Krisha
    Louder, Mark K.
    Ledgerwood, Julie E.
    Graham, Barney S.
    Haynes, Barton F.
    Burton, Dennis R.
    Wyatt, Richard T.
    Mascola, John R.
    [J]. JOURNAL OF VIROLOGY, 2011, 85 (17) : 8954 - 8967
  • [3] Population pharmacokinetics analysis of VRC01, an HIV-1 broadly neutralizing monoclonal antibody, in healthy adults
    Huang, Yunda
    Zhang, Lily
    Ledgerwood, Julie
    Grunenberg, Nicole
    Bailer, Robert
    Isaacs, Abby
    Seaton, Kelly
    Mayer, Kenneth H.
    Capparelli, Edmund
    Corey, Larry
    Gilbert, Peter B.
    [J]. MABS, 2017, 9 (05) : 792 - 800
  • [4] A Single Residue within the V5 Region of HIV-1 Envelope Facilitates Viral Escape from the Broadly Neutralizing Monoclonal Antibody VRC01
    Guo, Dongxing
    Shi, Xuanling
    Arledge, Kelly C.
    Song, Dingka
    Jiang, Liwei
    Fu, Lili
    Gong, Xinqi
    Zhang, Senyan
    Wang, Xinquan
    Zhang, Linqi
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (51) : 43170 - 43179
  • [5] Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults
    Ledgerwood, J. E.
    Coates, E. E.
    Yamshchikov, G.
    Saunders, J. G.
    Holman, L.
    Enama, M. E.
    DeZure, A.
    Lynch, R. M.
    Gordon, I.
    Plummer, S.
    Hendel, C. S.
    Pegu, A.
    Conan-Cibotti, M.
    Sitar, S.
    Bailer, R. T.
    Narpala, S.
    McDermott, A.
    Louder, M.
    O'Dell, S.
    Mohan, S.
    Pandey, J. P.
    Schwartz, R. M.
    Hu, Z.
    Koup, R. A.
    Capparelli, E.
    Mascola, J. R.
    Graham, B. S.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2015, 182 (03): : 289 - 301
  • [6] V5 region in the HIV-1 envelope glycoprotein determines viral sensitivity to the broadly neutralizing monoclonal antibody VRC01
    D Guo
    X Shi
    K Arledge
    D Song
    L Jiang
    L Fu
    S Zhang
    X Wang
    L Zhang
    [J]. Retrovirology, 9 (Suppl 2)
  • [7] Virus Fitness after Infusion with Broadly Neutralizing Antibody VRC01
    Lynch, Rebecca
    Madden, Patrick
    Boritz, Eli
    Coates, Emily
    Dezure, Adam
    Koup, Richard
    Graham, Barney
    Douek, Daniel
    Ledgerwood, Julie
    Mascola, John
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2016, 32 : 91 - 91
  • [8] V5 region in the HIV-1 envelope glycoprotein determines viral sensitivity to the broadly neutralizing monoclonal antibody VRC01
    Guo, D.
    Shi, X.
    Arledge, K.
    Song, D.
    Jiang, L.
    Fu, L.
    Zhang, S.
    Wang, X.
    Zhang, L.
    [J]. RETROVIROLOGY, 2012, 9
  • [9] HIV Broadly Neutralizing Antibodies: VRC01 and Beyond
    Wu, Xueling
    [J]. HIV VACCINES AND CURE: THE PATH TOWARDS FINDING AN EFFECTIVE CURE AND VACCINE, 2018, 1075 : 53 - 72
  • [10] Prevention efficacy of the broadly neutralizing antibody VRC01 depends on HIV-1 envelope sequence features
    Juraska, Michal
    Bai, Hongjun
    deCamp, Allan C.
    Magaret, Craig A.
    Li, Li
    Gillespie, Kevin
    Carpp, Lindsay N.
    Giorgi, Elena E.
    Ludwig, James
    Molitor, Cindy
    Hudson, Aaron
    Williamson, Brian D.
    Espy, Nicole
    Simpkins, Brian
    Rudnicki, Erika
    Shao, Danica
    Rossenkhan, Raabya
    Edlefsen, Paul T.
    Westfall, Dylan H.
    Deng, Wenjie
    Chen, Lennie
    Zhao, Hong
    Bhattacharya, Tanmoy
    Pankow, Alec
    Murrell, Ben
    Yssel, Anna
    Matten, David
    York, Talita
    Beaume, Nicolas
    Gwashu-Nyangiwe, Asanda
    Ndabambi, Nonkululeko
    Thebus, Ruwayhida
    Karuna, Shelly T.
    Morris, Lynn
    Montefiori, David C.
    Hural, John A.
    Cohen, Myron S.
    Corey, Lawrence
    Rolland, Morgane
    Gilbert, Peter B.
    Williamson, Carolyn
    Mullins, James I.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 121 (04)
12345