Hidden Markov models for the onset and progression of bronchiolitis obliterans syndrome in lung transplant recipients

被引：54
|
作者：
Jackson, CH [1 ]
Sharples, LD [1 ]
机构：
[1] Inst Publ Hlth, MRC, Biostat Unit, Cambridge CB4 2SR, England
来源：
STATISTICS IN MEDICINE | 2002年 / 21卷 / 01期
关键词：
hidden Markov models; bronchiolitis obliterans syndrome; lung transplant recipients; rejection in lung transplant recipients;
D O I：
10.1002/sim.886
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Chronic rejection in lung transplant recipients is monitored by repeated measurement of forced expiratory volume in one second (FEV1). This marker is measured at irregular intervals and is also affected by covariates and short-term fluctuation. This paper describes the use of hidden Markov models for the underlying staged functional decline. Maximum likelihood methods are used to simultaneously estimate disease progression rates and the effects of mismeasurement and covariates. Copyright C 2002 John Wiley Sons, Ltd.
引用
收藏
页码：113 / 128
页数：16
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