Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism

被引：42

作者：

Girard, J. ^{[3
]}

Lafontan, M. ^{[1
,2
]}

机构：

[1] Inst Louis Bugnard, INSERM, U858, Inst Med Mol Rangueil,IFR 31, F-31432 Toulouse 4, France

[2] Univ Toulouse 3, F-31062 Toulouse 9, France

[3] Univ Paris 05, CNRS, Inst Cochin, INSERM,U567,UMR 8104, F-75014 Paris, France

来源：

DIABETES & METABOLISM | 2008年 / 34卷 / 05期

关键词：

Hepatocytes; Fatty acids; Insulin resistance; Hepatic glucose production; Gluconeogenesis; Review;

D O I：

10.1016/j.diabet.2008.04.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Excess visceral adipose tissue is associated with anomalies of blood glucose homoeostasis, elevation of plasma triglycerides and low levels of high-density lipoprotein cholesterol that contribute to the development of type-2 diabetes and cardiovascular syndromes. Visceral adipose tissue releases a large amount of free fatty acids and hormones/cytokines in the portal vein that are delivered to the liver. The secreted products interact with hepatocytes and various immune cells in the liver. Altered liver metabolism and determinants of insulin resistance associated with visceral adipose tissue distribution are discussed, its well as, determinants of an insulin-resistant state promoted by the increased free fatty acids and cytokines delivered by visceral adipose tissue to the liver. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：439 / 445

页数：7

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