Retina (4) age-related macular degeneration The iron track

被引:2
|
作者
Courtois, Yves [1 ]
Youale, Jenny [1 ]
Behar-Cohen, Francine [2 ]
Picard, Emilie [1 ]
机构
[1] Univ Paris Diderot, Sorbonne Univ, USPC, Ctr Rech Cordeliers,Inserm,UMRS1138, 15 Rue Ecole Med, F-75006 Paris, France
[2] Hop Cochin, AP HP, 24 Rue Faubourg St Jacques, F-75014 Paris, France
来源
M S-MEDECINE SCIENCES | 2020年 / 36卷 / 6-7期
关键词
TRANSFERRIN RECEPTOR; EXPRESSION; HOMEOSTASIS; BINDING; GENE; HEMOCHROMATOSIS; ACCUMULATION; POLYMORPHISM; MELANOSOMES; COMPONENT;
D O I
10.1051/medsci/2020096
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Iron has a fundamental role for cell physiology and especially in retina as a cofactor of many pathways of the visual transduction. A tightly regulated homeostasis avoids the accumulation of prooxidant and proinflammatory free iron. A dysfunction of iron retinal homeostasis is associated with many genetic or age-related degenerative diseases such as age-related macular degeneration (AMD). Here, we describe various mechanisms reported during AMD, enhanced by iron accumulation and its homeostasis dysregulation. We have investigated a local treatment with transferrin, the natural iron carrier, to control these pathological pathways and iron dysfunction, without side effects. Iron has a central role in pathogenesis of AMD and is a target for futures therapies. © 2020 médecine/sciences - Inserm.; En raison de l'intense activité physiologique de la fonction visuelle, l'homéostasie du fer dans la rétine y est contrôlée localement. Sous l'effet de sa dérégulation (qui a des origines génétiques, environnementales, ou due au vieillissement), le fer libre s'accumule et devient, par ses propriétés oxydantes et inflammatoires, toxique, comme cela est observé au cours de la dégénérescence maculaire liée à l'âge (DMLA). Le rétablissement d'un métabolisme du fer équilibré est donc une possibilité thérapeutique. Néanmoins, la toxicité oculaire des chélateurs chimiques oriente les recherches vers des chélateurs biologiques naturels. Nos travaux montrent que la transferrine, le transporteur du fer, préserve la rétine des mécanismes associés à la DMLA. © 2020 médecine/sciences - Inserm.
引用
收藏
页码:616 / 625
页数:10
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