Lymphomagenic properties of a HIV p17 variant derived from a splenic marginal zone lymphoma occurred in a HIV-infected patient

被引:7
|
作者
Caccuri, Francesca [1 ]
Muraro, Elena [2 ]
Gloghini, Annunziata [3 ]
Turriziani, Ombretta [4 ]
Riminucci, Mara [4 ]
Giagulli, Cinzia [1 ]
Mastorci, Katy [2 ]
Fae, Damiana Antonia [2 ]
Fiorentini, Simona [1 ]
Caruso, Antonino [5 ]
Carbone, Arnaldo [1 ]
Dolcetti, Riccardo [2 ,6 ]
机构
[1] Univ Brescia, Sect Microbiol, Dept Mol & Translat Med, Brescia, Italy
[2] IRCCS, Ctr Riferimento Oncol Aviano, Dept Translat Res, Immunopathol & Biomarker Unit, Aviano, Italy
[3] Fdn IRCCS, Dept Pathol & Lab Med, Ist Nazl Tumori, Milan, Italy
[4] Sapienza Univ Rome, Dept Mol Med, Rome, Italy
[5] IRCCS, Ctr Riferimento Oncol Aviano, Dept Pathol, Aviano, Italy
[6] Univ Queensland, Diamantina Inst, Translat Res Inst, Brisbane, Qld, Australia
关键词
B lymphocytes; HIV; lymphomagenesis; marginal zone lymphoma; p17; MATRIX PROTEIN P17; UNITED-STATES; ANGIOGENESIS; CANCER; POPULATION; PROMOTES;
D O I
10.1002/hon.2562
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Despite antiretroviral therapy, HIV+ individuals still have increased risk to develop lymphomas, including marginal zone lymphomas, suggesting that factors other than HIV-related immunosuppression are probably acting as lymphomagenic factors in the HIV setting. The possible pathogenic involvement of HIV p17 protein variants was investigated in a particularly informative case of HIV-related splenic marginal zone lymphoma, which was negative for oncogenic virus infections, thus allowing us to assess the possible direct contribution of these HIV-encoded proteins to lymphomagenesis. The presence of p17 protein was analyzed by immunohistochemistry in lymphoma tissue. Recombinant p17 protein derived from the dominant sequence detected in plasma and lymphoma biopsy was characterized for B-cell proliferation, clonogenicity in soft agar, in vitro tube formation and wound healing. Intracellular signaling was investigated by immunoblotting. HIV p17 protein was detected in reactive lymphoid follicles but not within lymphoma cells. An identical dominant variant p17 sequence, p17-Lyrm, carrying a 117 to 118 Ala-Ala insertion was detected in both plasma and lymphoma tissue. Recombinant p17-Lyrm enhanced B-cell proliferation and clonogenicity promoted the formation of capillary-like structures and enhanced endothelial cell migration. Unlike reference p17, the p17-Lyrm variant enhanced the activation of Akt and ERK, critical kinases in lymphomagenesis. p17-Lyrm clonogenic activity was dependent on the activation of Akt but not of ERK1/2. These results indicated that HIV p17 variants with distinct molecular signatures and functional properties may accumulate in lymphoid tissues of HIV-infected individuals where they may act as a local stimulus promoting the development of lymphomas.
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收藏
页码:176 / 184
页数:9
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