Virological characterization of an infection with a dual-tropic, multidrug-resistant HIV-1 and further evolution on antiretroviral therapy

被引：4
|
作者：
Masquelier, Bernard [1 ]
Capdepont, Sophie
Neau, Didier
Peuchant, Olivia
Taupin, Jean-Luc
Coakley, Eoin
Lie, Yolanda
Carpentier, Wassila
Dabis, Francois
Fleury, Herve J. A.
机构：
[1] CHU Bordeaux, Dept Virol & Immunol Biol, Bordeaux, France
[2] CHU Bordeaux, Dept Malad Infect, Bordeaux, France
[3] Univ Victor Segalen, INSERM, U 593, ISPED, Bordeaux, France
[4] Monogram Biosci, San Francisco, CA USA
[5] INSERM, U543, Lab Immunol Cellulaire, Paris, France
来源：
AIDS | 2007年 / 21卷 / 01期
关键词：
D O I：
10.1097/QAD.0b013e3280117053
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We studied a case of recent infection with multidrug-resistant (MDR) HIV-1. Over 16 months off therapy, the CD4 cell count decreased from 419 to 184 cells/mu l. Antiretroviral therapy (ART) then led to an incomplete virological response but to an immunological benefit, concurrently with a shift to CCR5-only tropism and a reduction in replication capacity. ART, even if suboptimal, can be of interest in the case of MDR virus infection.
引用
收藏
页码：103 / 106
页数：4
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