In Vitro Bactericidal Activity of Trimethoprim-Sulfamethoxazole Alone and in Combination with Colistin against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates

被引：25
|
作者：
Nepka, Martha [1 ]
Perivolioti, Efstathia [1 ]
Kraniotaki, Eleni [1 ]
Politi, Lida [2 ]
Tsakris, Athanasios [2 ]
Pournaras, Spyros [2 ]
机构：
[1] Evaggelismos Gen Hosp, Dept Microbiol, Athens, Greece
[2] Univ Athens, Sch Med, Dept Microbiol, Athens, Greece
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 11期
关键词：
GRAM-NEGATIVE BACTERIA; CLONAL LINEAGES; INFECTION; EFFICACY; IMIPENEM; SYNERGY;
D O I：
10.1128/AAC.01082-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Trimethoprim-sulfamethoxazole alone and combined with colistin was tested in vitro against six carbapenem-resistant Acinetobacter baumannii (CRAB) clinical strains. After 24 h, at achievable serum concentrations, trimethoprim-sulfamethoxazole effectively killed all strains, while colistin killed only one strain. Trimethoprim-sulfamethoxazole plus colistin rapidly killed all strains after 6 h and for up to 24 h. Trimethoprim-sulfamethoxazole, one of the few remaining antimicrobials that still has a degree of activity, particularly combined with colistin, might represent an effective therapy for severe CRAB infections.
引用
收藏
页码：6903 / 6906
页数：4
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