A Visual Organic Chemistry Reaction: The Synthesis of 4-Amino-3-nitrobenzoic Acid Methyl Ester via Fischer Esterification

被引：4
|
作者：
Kam, Caleb M. T. [1 ]
Levonis, Stephan M. [1 ]
Schweiker, Stephanie S. [1 ]
机构：
[1] Bond Univ, Fac Hlth Sci & Med, Med Chem Grp, Robina, Qld 4229, Australia
来源：
JOURNAL OF CHEMICAL EDUCATION | 2020年 / 97卷 / 07期
关键词：
Esters; Synthesis; Second-Year Undergraduate; Organic Chemistry; Hands-On Learning/Manipulatives;
D O I：
10.1021/acs.jchemed.9b01168
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of 4-amino-3-nitrobenzoic acid methyl ester is a simple Fischer esterification reaction designed as an experiment for use in an introductory organic chemistry course. The compound was synthesized as a one-pot reaction within 30 min to 16 h, with 1 h producing a workable yield. The bright-yellow solid was purified using liquid-liquid extraction, and the extraction process was monitored by a marked color change. The product was then characterized by H-1 and C-13 NMR spectroscopy and thin-layer chromatography.
引用
收藏
页码：1997 / 2000
页数：4
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