Synthesis of Dipeptides by Boronic Acid Catalysis

被引：12

作者：

Tsuji, Hiroaki ^{[1
]}

Yamamoto, Hisashi ^{[1
]}

机构：

[1] Chubu Univ, Mol Catalyst Res Ctr, 1200 Matsumoto Cho, Kasugai, Aichi 4878501, Japan

来源：

SYNLETT | 2018年 / 29卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

N-hydroxy amino acid esters; amidation; boronic acid catalysis; N-hydroxy dipeptides; substrate-controlled reaction; ASYMMETRIC CATALYSIS; DIRECT AMIDATION; AMINO-ALCOHOLS; PEPTIDE-SYNTHESIS; ROOM-TEMPERATURE; ALPHA; ESTERS; AMIDE; CONDENSATION; LIGATIONS;

D O I：

10.1055/s-0036-1589130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have found that a boronic acid catalyzed amidation of an N-hydroxy amino acid methyl ester with amino acid tert-butyl esters gave N-hydroxy dipeptide derivatives in good yields without any racemization. The protecting groups on the nitrogen atom could be easily removed by heterogeneous hydrogenation conditions.

引用

页码：318 / 321

页数：4

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