Towards the elucidation of the true impact of adipocytokines on cardiovascular risk in rheumatoid arthritis

被引：8
|
作者：
Dessein, Patrick H. [1 ]
Solomon, Ahmed [2 ]
机构：
[1] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Cardiovasc Pathophysiol & Genom Res Unit, ZA-2193 Johannesburg, South Africa
[2] Univ Witwatersrand, Charlotte Maxeke Johannesburg Acad Hosp, Fac Hlth Sci, Dept Rheumatol, ZA-2193 Johannesburg, South Africa
来源：
ARTHRITIS RESEARCH & THERAPY | 2013年 / 15卷 / 06期
关键词：
DISEASE; BLACK;
D O I：
10.1186/ar4412
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Adipo(cyto) kines are mostly produced by adipose tissue and orchestrate the adverse impact of excess adiposity on cardiovascular risk. Adipokines also contribute importantly to the pathophysiology of rheumatoid arthritis. Congruent with data reported in previous investigations, Kang and colleagues report in this issue of Arthritis Research & Therapy that adipokine concentrations are further associated with metabolic risk and inflammation and that the leptin-adiponectin ratio associates with the carotid artery resistive index in rheumatoid arthritis. Guided by evidence reported thus far on cardiovascular risk, we discuss six reasons why careful elucidation of adipokine-cardiovascular risk relations is needed in rheumatoid arthritis.
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页数：2
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