Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus

被引:16
|
作者
Liu, Jun-Bao [1 ]
Jian, Tunyu [2 ]
Yue, Chao [3 ,4 ,5 ]
Chen, Dan [4 ,5 ,6 ]
Chen, Wei [4 ,5 ,7 ]
Bao, Ting-Ting [4 ,5 ,8 ]
Liu, Hai-Xia [9 ]
Cao, Yun [10 ]
Li, Wei-Bing [4 ,5 ,8 ]
Yang, Zhijian [11 ]
Hoffman, Robert M. [11 ]
Yu, Chen [4 ,5 ,8 ]
机构
[1] Zhengzhou Univ, Peoples Hosp, Peoples Hosp Henan Prov, Tradit Chinese Med Dept, Zhengzhou, Henan, Peoples R China
[2] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Gen Surg, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Jiangsu Inst Canc Res, Nanjing 210000, Jiangsu, Peoples R China
[5] Nanjing Med Univ, Affiliated Canc Hosp, Nanjing 210000, Jiangsu, Peoples R China
[6] Nanjing Med Univ, Jiangsu Canc Hosp, Res Ctr Clin Oncol, Nanjing, Jiangsu, Peoples R China
[7] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Head & Neck Surg, Nanjing, Jiangsu, Peoples R China
[8] Nanjing Med Univ, Dept Integrated TCM & Western Med, Jiangsu Canc Hosp, Nanjing 210000, Jiangsu, Peoples R China
[9] Nanjing Univ Chinese Med, Affiliated Hosp 2, Emergency Dept, Nanjing, Jiangsu, Peoples R China
[10] Nanjing Univ Chinese Med, Oncol, Nanjing, Jiangsu, Peoples R China
[11] AntiCanc Inc, San Diego, CA USA
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Dysregulated genes; gene ontology; KEGG pathway; gastric cancer; protein-protein interaction; chemoresistance; COMBINATION CHEMOTHERAPY; CISPLATIN; CHEMORESISTANCE; STATISTICS; DOCETAXEL; PATHWAY; PTEN; S-1;
D O I
10.21873/anticanres.13274
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background/Aim: This study aimed to identify biomarkers for predicting the prognosis of advanced gastric cancer patients who received docetaxel, cisplatin, and S-1 (DCS). Materials and Methods: Gene expression profiles were obtained from the Gene Expression Omnibus database (GSE31811). Gene-Ontology-enrichment and KEGG-pathway analysis were used for evaluating the biological functions of differentially-expressed genes. Protein-protein interaction (PPI) network and Kaplan-Meier survival analyses were employed to assess the prognostic values of hub genes. Results: A total of 1,486 differentially expressed genes (DEGs) were identified, including 13 up-regulated and 1,473 down-regulated genes. KEGG pathways such as metabolic pathways, cell adhesion molecules (CAMs), PI3K-Akt signaling pathway and pathways in cancer were significantly represented. In the PPI network, the top ten hub genes ranked by degree were GNG7, PLCB1, CALML5, FGFR4, GRB2, JAK3, ADCY7, ADCY9, GNAS and KDR. Five DEGs, including ANTXR1, EFNA5, GAMT, E2F2 and NRCAM, were associated with relapse-free survival and overall survival. Conclusion: ANTXR1, EFNA5, GAMT, E2F2 and NRCAM are potential biomarkers and therapeutic targets for DCS treatment in GC.
引用
收藏
页码:1689 / 1698
页数:10
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