Progressive Cholestasis and Biliary Cirrhosis After Initiating Oral Semaglutide: Report From the Drug-Induced Liver Injury Network

被引：5
|
作者：
Ma, Jiayi [1 ]
Mathur, Karan [1 ]
Muldoon, Jessica L. L. [2 ]
Ghabril, Marwan [1 ]
Chalasani, Naga [1 ]
Vuppalanchi, Raj [1 ]
机构：
[1] Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Pathol, Indianapolis, IN USA
来源：
ACG CASE REPORTS JOURNAL | 2022年 / 9卷 / 12期
关键词：
MUTATIONS; FEATURES; OUTCOMES;
D O I：
10.14309/crj.0000000000000922
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Semaglutide has little hepatic metabolism and is deemed low risk for causing drug-induced liver injury (DILI). We present a case of DILI from the US DILI Network. The case involved a 51-year-old man with type 2 diabetes who presented with jaundice and acute-on-chronic kidney disease 6 months after starting oral semaglutide. His liver injury progressed to biliary cirrhosis, accompanied by nephritis that led to end-stage renal disease. Extensive evaluations including liver and kidney biopsies revealed no alternative etiologies. Cholestatic gene sequencing revealed heterozygosity for ABCC2 and DHCR7. He eventually underwent combined liver and kidney transplantation.
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页数：4
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