DESIGN AND SYNTHESIS OF NOVEL OPIOID LIGANDS AND THEIR PHARMACOLOGIES

被引：6

作者：

Nagase, Hiroshi ^{[1
]}

Fujii, Hideaki ^{[1
]}

机构：

[1] Kitasato Univ, Sch Pharm, Minato Ku, Tokyo 1088641, Japan

来源：

HETEROCYCLES | 2012年 / 85卷 / 08期

关键词：

Naltrexone; Homogalanthamine; Oxazatricyclodecane Derivative; Triplet Drug; Propellane Derivative; PROTEIN-COUPLED RECEPTORS; RATIONAL DRUG DESIGN; NALTREXONE DERIVATIVES; BIOLOGICAL EVALUATION; PAIR ORIENTATION; AGONIST TRK-820; KAPPA-AGONIST; SKELETON; IDENTIFICATION; REARRANGEMENT;

D O I：

10.3987/REV-12-738

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the recent progress of our investigations in the opioid field in this review, which includes interesting reactions using naltrexone derivatives and pharmacological properties of the synthesized derivatives. Some reactions utilized the characteristic structural features of the morphinan skeleton, and others were applicable to general compounds. Some derivatives were expected to be lead compounds for developing novel ligands selective for the individual opioid receptor types. Triplet drugs consisting of three pharmacophore units in one molecule exhibited interesting pharmacological profiles and would be expected to be a useful tool for clarifying the pharmacology of receptor oligomerization.

引用

页码：1821 / 1867

页数：47

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