Ectodomain shedding and ADAMs in development

被引：208
|
作者：
Weber, Silvio [2 ]
Saftig, Paul [1 ]
机构：
[1] Univ Kiel, Inst Biochem, D-24098 Kiel, Germany
[2] Univ Gottingen, Univ Med Gottingen, Heart Res Ctr Gottingen, Dept Cardiol & Pneumol, D-3400 Gottingen, Germany
来源：
DEVELOPMENT | 2012年 / 139卷 / 20期
关键词：
ADAM; Notch; Ectodomain shedding; Cell fate determination; Differentiation; NECROSIS-FACTOR-ALPHA; METALLOPROTEASE-DISINTEGRIN ADAM8; CELL-CELL ADHESION; AMYLOID PRECURSOR PROTEIN; CRANIAL NEURAL CREST; SIGNAL PEPTIDE PEPTIDASES; CYSTEINE-RICH DOMAIN; SPERM-EGG FUSION; CONVERTING-ENZYME; GROWTH-FACTOR;
D O I：
10.1242/dev.076398
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Proteolytic enzymes belonging to the A Disintegin And Metalloproteinase (ADAM) family are able to cleave transmembrane proteins close to the cell surface, in a process referred to as ectodomain shedding. Substrates for ADAMs include growth factors, cytokines, chemokines and adhesion molecules, and, as such, many ADAM proteins play crucial roles in cell-cell adhesion, extracellular and intracellular signaling, cell differentiation and cell proliferation. In this Review, we summarize the fascinating roles of ADAMs in embryonic and adult tissue development in both vertebrates and invertebrates.
引用
收藏
页码：3693 / 3709
页数：17
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