Synthesis of dibenzofurans directly from aryl halides and ortho-bromophenols via one-pot consecutive SNAr and intramolecular palladium-catalyzed aryl-aryl coupling reactions

被引：24
|
作者：
Xu, Hui [1 ]
Fan, Ling-Ling [1 ]
机构：
[1] NW A&F Univ, Coll Sci, Lab Pharmaceut Synth, Yangling 712100, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 10期
关键词：
dibenzofuran; one-pot reaction; C(sp(2))-O bond formation reaction; aryl-aryl coupling reaction;
D O I：
10.1248/cpb.56.1496
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of dibenzofurans were efficiently and conveniently synthesized via one-pot consecutive C(sp(2))-O bond formation reaction (SNAr) in the presence of anhydrous K2CO3, followed by C(sp(2))-C(sp(2)) bond formation reaction (intramolecular palladium-catalyzed aryl-aryl coupling reaction) between aryl halides and ortho-bromophenols. The desired dibenzofurans were obtained in 32-99% isolated yields.
引用
收藏
页码：1496 / 1498
页数：3
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