Fetal alcohol syndrome: Craniofacial and central nervous system manifestations

被引:0
|
作者
Johnson, VP
Swayze, VW
Sato, Y
Andreasen, NC
机构
[1] UNIV S DAKOTA, SCH MED, DEPT OBSTET GYNECOL, BIRTH DEFECTS GENET CTR, SIOUX FALLS, SD USA
[2] UNIV S DAKOTA, SCH MED, DEPT PEDIAT, SIOUX FALLS, SD USA
[3] UNIV S DAKOTA, SCH MED, DEPT LAB MED, SIOUX FALLS, SD USA
[4] UNIV IOWA HOSP & CLIN, DEPT RADIOL, SCH MED, IOWA CITY, IA 52242 USA
[5] UNIV IOWA HOSP & CLIN, DEPT PSYCHIAT, SCH MED, IOWA CITY, IA 52242 USA
[6] VET ADM MED CTR, PSYCHIAT SERV, IOWA CITY, IA 52240 USA
来源
AMERICAN JOURNAL OF MEDICAL GENETICS | 1996年 / 61卷 / 04期
关键词
MRI; agenesis of the corpus callosum; cavum septi pellucidi; cavum vergae; median cleft face; frontonasal dysplasia; midline developmental field defect;
D O I
10.1002/(SICI)1096-8628(19960202)61:4<329::AID-AJMG6>3.0.CO;2-P
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Magnetic resonance imaging (MRI) is undertaken on fetal alcohol syndrome (FAS) subjects to document central nervous system (CNS) anomalies. The abnormalities found include agenesis and hypoplasia of the corpus callosum, cavum septi pellucidi, cavum vergae, ventriculomegaly, hypoplasia of inferior olivary eminences, small brain stem, and micrencephaly, Craniofacial anomalies range from the well-recognized FAS physiognomy to the more severe frontonasal. ''dysplasia'' (median cleft face), CNS and craniofacial abnormalities are predominantly symmetric and central or midline. The association of these anomalies becomes self evident with recognition of the concept of the midline as a special developmental field, vulnerable to adverse factors during embryogenesis and fetal growth and development. (C) 1996 Wiley-Liss, Inc.
引用
收藏
页码:329 / 339
页数:11
相关论文
共 50 条
  • [1] CRANIOFACIAL AND ORAL MANIFESTATIONS OF FETAL ALCOHOL SYNDROME
    JACKSON, IT
    HUSSAIN, K
    PLASTIC AND RECONSTRUCTIVE SURGERY, 1990, 85 (04) : 505 - 512
  • [2] Central Nervous System Manifestations of Antiphospholipid Syndrome
    Graf, Jonathan
    RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2017, 43 (04) : 547 - +
  • [3] Fetal alcohol syndrome:: abnormal development of the central nervous system and clinical phenotype.
    Vallée, L
    Cuvellier, JC
    PATHOLOGIE BIOLOGIE, 2001, 49 (09): : 732 - 737
  • [4] EVALUATION OF CENTRAL NERVOUS-SYSTEM TOXICITY IN THE FETAL ALCOHOL SYNDROME IN EXPERIMENTAL MICE
    THOMPSON, PA
    FOLB, PI
    TOXICOLOGY LETTERS, 1980, : 108 - 108
  • [5] SJOGREN SYNDROME - CENTRAL NERVOUS-SYSTEM MANIFESTATIONS
    ALEXANDER, GE
    PROVOST, TT
    STEVENS, MB
    ALEXANDER, EL
    NEUROLOGY, 1981, 31 (11) : 1391 - 1396
  • [6] Impaired development of mitochondria plays a role in the central nervous system defects of fetal alcohol syndrome
    Xu, YJ
    Liu, P
    Li, Y
    BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2005, 73 (02) : 83 - 91
  • [7] Loss of myelinated axons is specific to the central nervous system in a mouse model of the fetal alcohol syndrome
    Parson, SH
    Sojitra, NM
    JOURNAL OF ANATOMY, 1995, 187 : 739 - 748
  • [8] An update on the central nervous system manifestations of Li–Fraumeni syndrome
    Brent A. Orr
    Michael R. Clay
    Emilia M. Pinto
    Chimene Kesserwan
    Acta Neuropathologica, 2020, 139 : 669 - 687
  • [9] OCULAR MANIFESTATIONS IN FETAL ALCOHOL SYNDROME
    CHAN, T
    BOWELL, R
    OKEEFE, M
    LANIGAN, B
    BRITISH JOURNAL OF OPHTHALMOLOGY, 1991, 75 (09) : 524 - 526
  • [10] Ocular manifestations in fetal alcohol syndrome
    Ribeiro, I. M.
    Vale, P. J.
    Tenedorio, P. A.
    Rodrigues, P. A.
    Bilhoto, M. A.
    Pereira, H. C.
    EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2007, 17 (01) : 104 - 109