Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26

被引：11
|
作者：
Endo, R [1 ]
Ohtsubo, Y [1 ]
Tsuda, M [1 ]
Nagata, Y [1 ]
机构：
[1] Tohoku Univ, Grad Sch Life Sci, Dept Environm Life Sci, Sendai, Miyagi 9808577, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 04期
关键词：
biodegradation; sphingomonads; gamma-hexachlorocyclohexane; 2,5-dichlorophenol; 2.5-dichlorohydroquinone;
D O I：
10.1271/bbb.70.1029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The growth of a gamma-hexachlorocyclohexane (gamma-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by gamma-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for gamma-HCH degradation, suggesting that metabolites of gamma-HCH are toxic to UT26. Two metabolites of gamma-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during gamma-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.
引用
收藏
页码：1029 / 1032
页数：4
相关论文
共 50 条
  • [1] Crystal Structure of γ-Hexachlorocyclohexane Dehydrochlorinase LinA from Sphingobium japonicum UT26
    Okai, Masahiko
    Kubota, Keiko
    Fukuda, Masao
    Nagata, Yuji
    Negata, Koji
    Tanokura, Masaru
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2010, 403 (02) : 260 - 269
  • [2] Distribution of γ-hexachlorocyclohexane-degrading genes on three replicons in Sphingobium japonicum UT26
    Nagata, Y
    Kamakura, M
    Endo, R
    Miyazaki, R
    Ohtsubo, Y
    Tsuda, M
    [J]. FEMS MICROBIOLOGY LETTERS, 2006, 256 (01) : 112 - 118
  • [3] Complete Genome Sequence of the Representative γ-Hexachlorocyclohexane-Degrading Bacterium Sphingobium japonicum UT26
    Nagata, Yuji
    Ohtsubo, Yoshiyuki
    Endo, Ryo
    Ichikawa, Natsuko
    Ankai, Akiho
    Oguchi, Akio
    Fukui, Shigehiro
    Fujita, Nobuyuki
    Tsuda, Masataka
    [J]. JOURNAL OF BACTERIOLOGY, 2010, 192 (21) : 5852 - 5853
  • [4] Organization and dynamism of gamma-hexachlorocyclohexane-degrading bacterium Sphingobium japonicum UT26 genome
    Nagata, Yuji
    Natsui, Shunsuke
    Ohtsubo, Yoshiyuki
    Ichikawa, Natsuko
    Ankai, Akiho
    Oguchi, Akio
    [J]. JOURNAL OF BIOTECHNOLOGY, 2010, 150 : S46 - S46
  • [5] Crystallization and preliminary X-ray analysis of γ-hexachlorocyclohexane dehydrochlorinase LinA from Sphingobium japonicum UT26
    Okai, Masahiko
    Kubota, Keiko
    Fukuda, Masao
    Nagata, Yuji
    Nagata, Koji
    Tanokura, Masaru
    [J]. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2009, 65 : 822 - 824
  • [6] Genomic organization and genomic structural rearrangements of Sphingobium japonicum UT26, an archetypal γ-hexachlorocyclohexane-degrading bacterium
    Nagata, Yuji
    Natsui, Shunsuke
    Endo, Ryo
    Ohtsubo, Yoshiyuki
    Ichikawa, Natsuko
    Ankai, Akiho
    Oguchi, Akio
    Fukui, Shigehiro
    Fujita, Nobuyuki
    Tsuda, Masataka
    [J]. ENZYME AND MICROBIAL TECHNOLOGY, 2011, 49 (6-7) : 499 - 508
  • [7] Differences in crystallization of two LinB variants from Sphingobium japonicum UT26
    Degtjarik, Oksana
    Chaloupkova, Radka
    Rezacova, Pavlina
    Kuty, Michal
    Damborsky, Jiri
    Smatanova, Ivana Kuta
    [J]. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2013, 69 : 284 - 287
  • [8] Identification and characterization of genes encoding a putative ABC-type transporter essential for utilization of γ-hexachlorocyclohexane in Sphingobium japonicum UT26
    Endo, Ryo
    Ohtsubo, Yoshiyuki
    Tsuda, Masataka
    Nagata, Yuji
    [J]. JOURNAL OF BACTERIOLOGY, 2007, 189 (10) : 3712 - 3720
  • [9] Simultaneous degradation of organophosphate and organochlorine pesticides by Sphingobium japonicum UT26 with surface-displayed organophosphorus hydrolase
    Xiangyu Cao
    Chao Yang
    Ruihua Liu
    Qiang Li
    Wei Zhang
    Jianli Liu
    Cunjiang Song
    Chuanling Qiao
    Ashok Mulchandani
    [J]. Biodegradation, 2013, 24 : 295 - 303
  • [10] Simultaneous degradation of organophosphate and organochlorine pesticides by Sphingobium japonicum UT26 with surface-displayed organophosphorus hydrolase
    Cao, Xiangyu
    Yang, Chao
    Liu, Ruihua
    Li, Qiang
    Zhang, Wei
    Liu, Jianli
    Song, Cunjiang
    Qiao, Chuanling
    Mulchandani, Ashok
    [J]. BIODEGRADATION, 2013, 24 (02) : 295 - 303
12345