Microenvironment-Mediated Resistance to Anti-Androgen Therapy

被引：8
|
作者：
Orme, Jacob J. [1 ,2 ]
Huang, Haojie [2 ,3 ,4 ]
机构：
[1] Mayo Clin, Coll Med & Sci, Dept Internal Med, Div Med Oncol, Rochester, MN USA
[2] Mayo Clin, Coll Med & Sci, Canc Ctr, Rochester, MN 55905 USA
[3] Mayo Clin, Coll Med & Sci, Dept Urol, Rochester, MN 55905 USA
[4] Mayo Clin, Coll Med & Sci, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
来源：
CANCER CELL | 2020年 / 38卷 / 02期
关键词：
PHASE-II; MODULATION;
D O I：
10.1016/j.ccell.2020.07.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Zhang et al. expose new possibilities for targeting castration-resistant prostate cancer (CRPC). Activation of the HER2/HER3 axis by cancer-associated fibroblast-secreted NRG1 mediates castration resistance, recommending novel applications of clinical anti-NRG1/HER3 therapeutics in treating CRPC.
引用
收藏
页码：155 / 157
页数：3
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