Clinical Trials of Aspirin Treatment After Desensitization in Aspirin-Exacerbated Respiratory Disease

被引：11

作者：

Kowalski, Marek L. ^{[1
]}

Wardzynska, Aleksandra ^{[1
]}

Makowska, Joanna S. ^{[2
]}

机构：

[1] Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Hlth Ageing Res Ctr, 251 Pomorska St, PL-92213 Lodz, Poland

[2] Med Univ Lodz, Dept Rheumatol, 30 Pieniny St, PL-92115 Lodz, Poland

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 04期

关键词：

Aspirin hypersensitivity; Aspirin desensitization; Nonsteroidal anti-inflammatory drugs; NSAIDs-exacerbated respiratory disease; Asthma; Chronic rhinosinusitis; SENSITIVE RHINOSINUSITIS-ASTHMA; INTRANASAL LYSINE-ASPIRIN; LONG-TERM TREATMENT; LOW-DOSE ASPIRIN; NASAL POLYPOSIS; MANAGEMENT; TOLERANCE; OUTCOMES; AERD;

D O I：

10.1016/j.iac.2016.06.007

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The clinical efficacy of aspirin treatment after desensitization in patients with respiratory disease exacerbated by nonsteroidal anti-inflammatory drugs has been documented in observational studies and in double-blind placebo-controlled trials. There is no general agreement with regard to the optimal maintenance dose or duration of treatment with acetylsalicylic acid after desensitization, thus further studies are necessary to offer clear guidelines to clinicians. This article summarizes data from noncontrolled, active-control, and placebo-controlled trials assessing clinical effectiveness and reporting on safety of treatment with acetylsalicylic acid in desensitized patients with respiratory disease exacerbated by nonsteroidal anti-inflammatory drugs.

引用

页码：705 / +

页数：14

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