The search for ESR1 mutations in breast cancer

被引：58
|
作者：
Oesterreich, Steffi [1 ,2 ,3 ,4 ]
Davidson, Nancy E. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Womens Canc Res Ctr, Inst Canc, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Dept Med, Womens Canc Res Ctr, Inst Canc, Pittsburgh, PA USA
[3] UPMC Canc Ctr, Pittsburgh, PA USA
[4] Magee Womens Res Inst, Pittsburgh, PA USA
来源：
NATURE GENETICS | 2013年 / 45卷 / 12期
关键词：
HUMAN ESTROGEN-RECEPTOR; TRANSCRIPTIONAL ACTIVITY; PHOSPHORYLATION; IDENTIFICATION; ACTIVATION;
D O I：
10.1038/ng.2831
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Two new studies report the identification of activating ESR1 gene mutations in aromatase inhibitor-resistant metastatic breast cancers. This insight into therapeutic resistance suggests new approaches that may be useful in the management of endocrine-resistant breast cancer.
引用
收藏
页码：1415 / 1416
页数：2
相关论文
共 50 条
  • [1] The search for ESR1 mutations in breast cancer
    Steffi Oesterreich
    Nancy E Davidson
    [J]. Nature Genetics, 2013, 45 : 1415 - 1416
  • [2] ESR1 mutations in breast cancer
    Clatot, Florian
    Augusto, Laetitia
    Di Fiore, Frederic
    [J]. AGING-US, 2017, 9 (01): : 17 - 18
  • [3] ESR1 mutations in breast cancer
    Dustin, Derek
    Gu, Guowei
    Fuqua, Suzanne A. W.
    [J]. CANCER, 2019, 125 (21) : 3714 - 3728
  • [4] Recurrent ESR1 mutations activating mutations in breast cancer
    Jeselsohn, R.
    [J]. CANCER RESEARCH, 2019, 79 (04)
  • [5] ESR1 mutations: a new biomarker in breast cancer
    Carausu, Marcela
    Bidard, Francois-Clement
    Callens, Celine
    Melaabi, Samia
    Jeannot, Emmanuelle
    Pierga, Jean-Yves
    Cabel, Luc
    [J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2019, 19 (07) : 599 - 611
  • [6] ESR1 mutations in metachronous contralateral breast cancer
    Velthuisen, D.
    Akkers, R.
    Menke-Pluijmers, M.
    Kitzen, J.
    Westenend, P.
    [J]. EUROPEAN JOURNAL OF CANCER, 2020, 138 : S124 - S124
  • [7] ESR1 mutations confer radiation resistance in breast cancer
    Udden, Nashir
    Wang, Qian
    Alluri, Prasanna G.
    [J]. CANCER RESEARCH, 2020, 80 (04)
  • [8] The Impact of ESR1 Mutations on the Treatment of Metastatic Breast Cancer
    Pejerrey, Sasha M.
    Dustin, Derek
    Kim, Jin-Ah
    Gu, Guowei
    Rechoum, Yassine
    Fuqua, Suzanne A. W.
    [J]. HORMONES & CANCER, 2018, 9 (04): : 215 - 228
  • [9] The Impact of ESR1 Mutations on the Treatment of Metastatic Breast Cancer
    Sasha M. Pejerrey
    Derek Dustin
    Jin-Ah Kim
    Guowei Gu
    Yassine Rechoum
    Suzanne A. W. Fuqua
    [J]. Hormones and Cancer, 2018, 9 : 215 - 228
  • [10] ESR1 mutations in metastatic lobular breast cancer patients
    Christine Desmedt
    Julien Pingitore
    Françoise Rothé
    Caterina Marchio
    Florian Clatot
    Ghizlane Rouas
    François Richard
    François Bertucci
    Odette Mariani
    Christine Galant
    Charlotte Fribbens
    Ben O’Leary
    Gert van den Eynden
    Roberto Salgado
    Nicholas C. Turner
    Martine Piccart
    Anne Vincent-Salomon
    Giancarlo Pruneri
    Denis Larsimont
    Christos Sotiriou
    [J]. npj Breast Cancer, 5
12345