The Role of the Catechol-O-Methyltransferase (COMT) Gene in Personality and Related Psychopathological Disorders

被引：55
|
作者：
Montag, Christian [1 ,2 ,3 ]
Jurkiewicz, Magdalena [4 ]
Reuter, Martin [1 ,2 ,3 ]
机构：
[1] Univ Bonn, Dept Psychol, D-53111 Bonn, Germany
[2] Univ Bonn, Neurogenet Lab, D-53111 Bonn, Germany
[3] Univ Bonn, Ctr Econ & Neurosci, D-53111 Bonn, Germany
[4] SUNY Stony Brook, Med Scientist Training Program, Stony Brook, NY 11794 USA
来源：
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2012年 / 11卷 / 03期
关键词：
COMT Val158Met; personality; genetic imaging; anxiety; anxiety disorders; catechol-o-methyltransferase; dopamine; DOPAMINE TRANSPORTER AVAILABILITY; OBSESSIVE-COMPULSIVE DISORDER; MONOAMINE-OXIDASE-A; GRAY-MATTER VOLUME; VAL(158)MET GENOTYPE; VAL158MET POLYMORPHISM; NOVELTY SEEKING; BDNF VAL66MET; RECEPTOR GENE; ENVIRONMENTAL-INFLUENCES;
D O I：
10.2174/187152712800672382
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This review provides a short overview of the most significant biologically oriented theories of human personality. Personality concepts of Eysenck, Gray and McNaughton, Cloninger and Panksepp will be introduced and the focal evidence for the heritability of personality will be summarized. In this context, a synopsis of a large number of COMT genetic association studies (with a focus on the COMT Val158Met polymorphism) in the framework of the introduced biologically oriented personality theories will be given. In line with the theory of a continuum model between healthy anxious behavior and related psychopathological behavior, the role of the COMT gene in anxiety disorders will be discussed. A final outlook considers new research strategies such as genetic imaging and epigenetics for a better understanding of human personality.
引用
收藏
页码：236 / 250
页数：15
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