Degradation of core-shell Au@SiO2 nanoparticles in biological media

被引：7

作者：

Ryabchikova, Elena I. ^{[1
,3
]}

Chelobanov, Boris P. ^{[1
,3
]}

Parkhomenko, Roman G. ^{[2
]}

Korchagina, Kseniya V. ^{[1
]}

Basova, Tamara V. ^{[2
,3
]}

机构：

[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Lavrentiev Pr 8, Novosibirsk 630090, Russia

[2] Russian Acad Sci, Nikolaev Inst Inorgan Chem, Siberian Branch, Lavrentiev Pr 3, Novosibirsk 630090, Russia

[3] Novosibirsk State Univ, Pirogova Str 2, Novosibirsk, Russia

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2017年 / 248卷

基金：

俄罗斯基础研究基金会;

关键词：

Gold core-mesoporous silica shell nanoparticles; Mesoporous silica; Transmission electron microscopy; Eukaryotic cells; MESOPOROUS SILICA NANOPARTICLES; GOLD NANOPARTICLES; CANCER-THERAPY; SURFACE CHARACTERISTICS; PLASMON RESONANCE; DRUG-DELIVERY; GROWTH; GEOMETRY; NANORODS; BEHAVIOR;

D O I：

10.1016/j.micromeso.2017.04.006

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this work, the effect of a cell culture medium on the integrity of mesoporous silica shell of gold-core nanoparticles (Au@SiO2 NPs) and their behavior in cells of HeLa, MDA-MB and BT cultures were studied using the method of transmission electron microscopy. It was shown that degradation of Au@SiO2 NPs takes place in the culture medium. The presence of the cells and serum does not influence on the process of the mesoporous silica layer degradation. The presence of both damaged and undamaged NPs in endosomes and lysosomes is related to different time of NPs' location outside of the cell, i.e. in culture medium. The analysis of the cell ultrastructure leads to a conclusion that the internal conditions in endosomes/lysosomes do not influence on the integrity of Au@SiO2 NPs. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：46 / 53

页数：8

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