Thermal characterization and compatibility studies of norfloxacin for development of extended release tablets

被引：22

作者：

Oliveira, P. R. ^{[1
]}

Bernardi, L. S. ^{[1
]}

Murakami, F. S. ^{[1
]}

Mendes, C. ^{[1
]}

Silva, M. A. S. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Dept Pharmaceut Sci, Hlth Sci Ctr, BR-88040900 Florianopolis, SC, Brazil

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2009年 / 97卷 / 02期

关键词：

Norfloxacin; Thermal characterization; Kinetic studies; Compatibility studies; NONISOTHERMAL CONDITIONS; DECOMPOSITION KINETICS; DOSAGE FORMS; DSC; QUINOLONES; BEHAVIOR; FORMULATIONS; EXCIPIENTS; HPMC;

D O I：

10.1007/s10973-009-0347-2

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Norfloxacin (NFX) is a synthetic antibacterial drug. The development of extended release tablets improves the patients' comfort and compliance, resulting in lower discontinuation of the therapy; with consequently decrease in bacterial resistance. In the present work, the thermal behavior of NFX was investigated using TG and DSC techniques. Isothermal and non-isothermal methods were employed to determine kinetic data of decomposition process. Compatibility studies between NFX and pharmaceutical excipients, including three hydrophilic polymers were carried out in order to develop a new formulation of NFX to obtain extended release tablets with an approved quality.

引用

页码：741 / 745

页数：5

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