ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A MIGICCL Study

被引：8

作者：

Carolina Bekker-Mendez, Vilma ^{[1
]}

Carlos Nunez-Enriquez, Juan ^{[2
]}

Tones Escalante, Jose Luis ^{[3
]}

Alvarez-Olmos, Enrique ^{[4
]}

Miguel Gonzalez-Montalvoc, Pablo ^{[5
]}

Jimenez-Hernandez, Elva ^{[6
]}

Medina Sanson, Aurora ^{[7
]}

Leal, Yelda A. ^{[8
]}

Teresa Ramos-Cervantes, Maria ^{[1
]}

Xavier Guerra-Castillo, Francisco ^{[1
]}

Patricia Ortiz-Maganda, Monica ^{[1
]}

Flores-Lujano, Janet ^{[2
]}

Luisa Perez-Saldivar, Maria ^{[2
]}

Margarita Velazquez-Avina, Martha ^{[9
]}

Bolea-Murga, Victoria ^{[10
]}

Refugio Torres-Nava, Jose ^{[11
]}

Amador-Sanchez, Raquel ^{[12
]}

Anastacia Solis-Labastida, Karma ^{[13
]}

Ramirez-Bello, Julian ^{[14
]}

Manuel Fragoso, Jose ^{[15
]}

Manuel Mejia-Arangure, Juan ^{[2
,16
]}

机构：

[1] Hosp Infectol Dr Daniel Mendez Hernandez La Raza, IMSS, Unidad Invest Med Inmunol & Infectol, Mexico City, DF, Mexico

[2] UMAE Hosp Pediat, Ctr Med Nacl Siglo 21, Inst Mexicano Seguro Social, Unidad Invest Med Epidemiol Clin, Mexico City, DF, Mexico

[3] UMAE, Inst Mexicano Seguro Social, Serv Pediat, Yucatan, Mexico

[4] Inst Nacl Med Genom INMEGEN, Lab Genom Canc, Mexico City, DF, Mexico

[5] Hosp Ohoran, Serv Oncolo Pediat, Yucatan, Mexico

[6] Hosp Gen Gaudencio Gonzalez Garza, Ctr Med Nacl La Raza, Serv Hematol Pediat, Mexico City, DF, Mexico

[7] Hosp Infantil Mexico Dr Federico Gomez, Serv Hematooncol, Secretaria Salud SSa, Mexico City, DF, Mexico

[8] Unidad Med Alta Especialidad IMSS Merida, Unidad Invest Med Yucatan, Registro Canc, Yucatan, Mexico

[9] Hosp Juarez Mexico, Serv Oncopediat, Secretaria Salud SSa, Mexico City, DF, Mexico

[10] Hosp Gen Mexico City, Serv Hematol Pediat, Secretaria Salud SSa, Mexico City, DF, Mexico

[11] Hosp Pediat Moctezuma, Secretaria Salud DF Mexico, Mexico City, DF, Mexico

[12] Hosp Gen Reg 1 Carlos McGregor Sanchez Navarro, IMSS, Mexico City, DF, Mexico

[13] UMAE Hosp Pediat, Ctr Med Nacl Siglo 21, IMSS, Serv Hematol Pediat, Mexico City, DF, Mexico

[14] Hosp Juarez Mexico, Lab Unidad Invest Enfermedades Metab & Endocrinas, Mexico City, DF, Mexico

[15] Inst Nacl Cardiol Ignacio Chavez, Dept Biol Mol, Ciudad De Mexico, Mexico

[16] IMSS, Coordinac Invest Salud, Mexico City, DF, Mexico

[17] Inst Mexicano Seguro Social, Inst Seguridad Social Serv Trabajadores Estado, Mexican Interinst Grp Identificat Causes Childhoo, Secretaria Salud Gobierno, Mexico City, DF, Mexico

来源：

ARCHIVES OF MEDICAL RESEARCH | 2016年 / 47卷 / 08期

关键词：

Association study; ARID5B; PIP4K2A; CEBPE; Childhood acute lymphoblastic leukemia; Mexican; SUSCEPTIBILITY LOCI; IKZF1; VARIANTS; ASSOCIATION; RS10821936; CANCER;

D O I：

10.1016/j.arcmed.2016.12.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background and Aims. Childhood acute lymphoblastic leukemia (ALL) is the leading cause of childhood cancer-related deaths worldwide. Multiples studies have shown that ALL seems to be originated by an interaction between environmental and genetic susceptibility factors. The ARID5B polymorphisms are among the most reproducible ALL associated-risk alleles in different populations. The aim of the present study was to examine the contribution of ARID5B, CEBPE, and PIP4K2 risk alleles for the development of ALL in children from Mexico City and Yucatan, Mexico. Methods. A study was conducted with a total of 761 unrelated subjects. Two hundred eighty five ALL cases (111 from Yucatan and 174 from Mexico City) and 476 healthy subjects. Genotyping included the rs7088318 (PIP4K2A), rs10821936 (ARID5B), rs7089424 (ARID5B) and rs2239633 (CEBPE) polymorphisms. Results. Associations between ALL and rs10821936 and rs7089424 ARID5B SNPs were found (OR = 1.9, 95% CI (1.5-2.4) and OR = 2.0, 95% CI (1.6-2.5), respectively). Moreover, a higher risk was observed in the homozygous risk genotypes of carriers from Mexico City (OR = 3.1, 95% CI (2.0-4.9) and OR 3.1, CI 95% (2.0-4.8), respectively). Otherwise, the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk. Conclusions. Our analysis suggests that ARID5B confers risk for childhood ALL in a Mexican population. (C) 2016 IMSS. Published by Elsevier Inc.

引用

页码：623 / 628

页数：6

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