Synthesis and antimicrobial activity of some novel hydrazide, benzochromenone, dihydropyridine, pyrrole, thiazole and thiophene derivatives

被引：76

作者：

Refat, Hala M. ^{[1
]}

Fadda, A. A. ^{[2
]}

机构：

[1] Suez Canal Univ, Dept Chem, Fac Educ, Al Arish, Egypt

[2] Mansoura Univ, Fac Sci, Dept Chem, ET-35516 Mansoura, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 70卷

关键词：

Benzochromenone; Acetohydrazide; Hydrazide-hydrazone; Antimicrobial activities; HETEROCYCLIC SYNTHESIS; ACTIVATED NITRILES; CHROMENE; PYRIDINE; UTILITY; ACID;

D O I：

10.1016/j.ejmech.2013.09.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a part of ongoing studies in developing new potent antimicrobial agents, a novel synthesis of 2-cyano-N-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)acetohydrazide (3) has been reported. The latter compound was reacted with different reagents to give new heterocyclic compounds. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, H-1 NMR, C-13 NMR and mass spectral data. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：419 / 426

页数：8

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