Fast and accurate water content and T2*mapping in brain tumours localised with FET-PET

被引：9
|
作者：
Oros-Peusquens, A. -M. [1 ]
Keil, F. [1 ]
Langen, K. J. [1 ]
Herzog, H. [1 ]
Stoffels, G. [1 ]
Weiss, C. [2 ]
Shah, N. J. [1 ,3 ]
机构：
[1] Res Ctr Juelich, Inst Neurosci & Med 4, D-52425 Julich, Germany
[2] Univ Hosp Cologne, Dept Neurosurg, D-50924 Cologne, Germany
[3] Rhein Westfal TH Aachen, Dept Neurol, Fac Med, JARA, D-52074 Aachen, Germany
来源：
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT | 2014年 / 734卷
关键词：
MR-PET; Quantitative MRI; Brain imaging; Glioblastoma patients; Water content; Transversal relaxation time; QUANTITATIVE MRI; IN-VIVO; GLIOMAS; FIELD;
D O I：
10.1016/j.nima.2013.09.045
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
The availability of combined MR-PET scanners opens new opportunities for the characterisation of tumour environment. In this study, water content and relaxation properties of glioblastoma were investigated in five patients using advanced MRI. The region containing metabolically active tumour tissue was defined by simultaneously measured FET-PET uptake. The mean value of water content in tumour tissue - obtained noninvasively with high precision and accuracy for the first time - amounted to 84.5%, similar to the value for normal grey matter. Constancy of water content contrasted with a large variability of T2* values in tumour tissue, qualitatively related to the magnetic inhomogeneity of tissue created by blood vessels and/or microbleeds. The quantitative MRI protocol takes 71/2 min of measurement time and is proposed for extended clinical use. (C) 2013 Elsevier BM. All rights reserved
引用
收藏
页码：185 / 190
页数：6
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