Non-Invasive Prenatal Testing for Down's Syndrome: Pregnant Women's Views and Likely Uptake

被引:98
|
作者
Lewis, C. [1 ]
Silcock, C. [2 ]
Chitty, L. S. [3 ,4 ,5 ]
机构
[1] Univ Coll London Hosp, NHS Fdn Trust, Genet Alliance UK, London, England
[2] Univ Coll London Hosp, NHS Fdn Trust, Inst Womens Hlth, London, England
[3] Univ Coll London Hosp, NHS Fdn Trust, Fetal Med Unit, London, England
[4] NHS Fdn Trust, UCL Inst Child Hlth, London, England
[5] NHS Fdn Trust, Great Ormond St Hosp Children, London, England
关键词
Aneuploidy; Cell-free fetal DNA; Down's syndrome; Non-invasive prenatal testing; FREE FETAL DNA; MATERNAL PLASMA; CHROMOSOMAL-ABNORMALITIES; DIAGNOSIS; ATTITUDES; PREFERENCES;
D O I
10.1159/000353523
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: The introduction of non-invasive prenatal testing (NIPT) for Down's syndrome into routine state-funded antenatal care in the UK is approaching. Methods: We conducted qualitative one-to-one interviews with 40 pregnant women to ascertain their views on using NIPT for Down's syndrome. Results: The overwhelming majority of women viewed NIPT as a positive advancement in prenatal care, highlighting numerous practical and psychological advantages of a safe test that was highly accurate and could be conducted early in pregnancy. Concerns raised were that testing could become routinised, and that pressure to test might occur with women feeling less justified in declining a blood test that is available and offered by trusted health professionals; the impact on the disabled community and stigma for women who decline testing was also noted. Nevertheless, the vast majority of women said they would be likely to use NIPT, including half of the women who currently decline screening. Women's preference was for pre- and post-test counselling to be delivered by a midwife. Conclusion: The successful introduction of NIPT into routine prenatal care will require guidelines and counselling strategies which ensure women are offered this test in a way which safeguards informed consent. (C) 2013 S. Karger AG, Basel
引用
收藏
页码:223 / 232
页数:10
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