Room temperature Au(I)-catalyzed exo-selective cycloisomerization of acetylenic acids:: An entry to functionalized γ-lactones

被引：237
|
作者：
Genin, E [1 ]
Toullec, PY [1 ]
Antoniotti, S [1 ]
Brancour, C [1 ]
Genêt, JP [1 ]
Michelet, V [1 ]
机构：
[1] ENSCP, Lab Synth Select Organ & Prod Nat, UMR 7573, F-75231 Paris 05, France
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 10期
关键词：
D O I：
10.1021/ja056857j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient gold-catalyzed cyclization reaction of various functionalized acetylenic acids is described. The cyclizations are conducted in the presence of Au(I) catalyst in acetonitrile at room temperature in a short reaction time. The reaction conditions are compatible with several functional groups, such as ester, alkene, alkyne, chloro, and free or protected alcohol, and lead to original γ-lactones in good to excellent yields. Copyright © 2006 American Chemical Society.
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收藏
页码：3112 / 3113
页数：2
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