RASAL2: Wrestling in the Combat of Ras Activation

被引：9

作者：

Shen, Jia ^{[1
,2
]}

Wang, Yan ^{[1
]}

Hung, Mien-Chie ^{[1
,2
,3
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[2] Univ Texas Houston, Grad Sch Biomed Sci, Houston, TX 77030 USA

[3] China Med Univ, Ctr Mol Med, Taichung 402, Taiwan

[4] China Med Univ, Grad Inst Canc Biol, Taichung 402, Taiwan

来源：

CANCER CELL | 2013年 / 24卷 / 03期

关键词：

BREAST-CANCER; METHYLATION; ONCOGENES; PROTEINS; GAPS; GEFS;

D O I：

10.1016/j.ccr.2013.08.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncogenic activation of Ras proteins due to missense mutations is frequently detected in human cancers but rarely in breast cancer. In this issue of Cancer Cell, McLaughlin and colleagues report that ablation of the GasGAP gene, RASAL2, is an alternative mechanism by which Ras becomes activated in breast cancer.

引用

页码：277 / 279

页数：3

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