Expression of carbonic anhydrase IV in carbonic anhydrase II-deficient mice

被引：22
|
作者：
Brion, LP
Cammer, W
Satlin, LM
Suarez, C
Zavilowitz, BJ
Schuster, VL
机构：
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10461 USA
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT NEUROL, BRONX, NY 10461 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 1997年 / 273卷 / 02期
关键词：
carbonic anhydrase isozymes I; II; III; and IV; carbonic anhydrase II deficiency; hydratase activity; cortex; outer medulla; liver; lung; affinity chromatography; renal tubular acidosis; regulation;
D O I：
10.1152/ajprenal.1997.273.2.F234
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Chronic metabolic acidosis (CMA) in the rabbit upregulates carbonic anhydrase (CA) TV in the proximal convoluted tubule (PCT). This study was designed to assess CA IV expression in a model of CMA in the mouse, i.e., congenital deficiency in CA II [CA(II)D]. In female CA(II)D mice, CA IV specific activity but not CA TV immunoreactivity was upregulated in the renal cortex, specifically in microdissected PCTs. Western blot analysis showed higher expression of CA IV immunoreactive protein in renal membranes from males than in those from females.
引用
收藏
页码：F234 / F245
页数：12
相关论文
共 50 条
  • [1] Respiratory acidosis in carbonic anhydrase II-deficient mice
    Lien, YHH
    Lai, LW
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1998, 274 (02) : L301 - L304
  • [2] Phenotypic characteristics of bone in carbonic anhydrase II-deficient mice
    Margolis, David S.
    Szivek, John A.
    Lai, Li-Wen
    Lien, Yeong-Hau H.
    [J]. CALCIFIED TISSUE INTERNATIONAL, 2008, 82 (01) : 66 - 76
  • [3] Phenotypic Characteristics of Bone in Carbonic Anhydrase II-Deficient Mice
    David S. Margolis
    John A. Szivek
    Li-Wen Lai
    Yeong-Hau H. Lien
    [J]. Calcified Tissue International, 2008, 82 : 66 - 76
  • [4] A single copy of Carbonic anhydrase 2 restores wild-type circadian period to carbonic anhydrase II-deficient mice
    Kernek, KL
    Trofatter, JA
    Mayeda, AR
    Lahiri, DK
    Hofstetter, JR
    [J]. BEHAVIOR GENETICS, 2006, 36 (02) : 301 - 308
  • [5] A Single Copy of Carbonic anhydrase 2 Restores Wild-type Circadian Period to Carbonic Anhydrase II-Deficient Mice
    Kari L. Kernek
    James A. Trofatter
    Aimee R. Mayeda
    Debomoy K. Lahiri
    John R. Hofstetter
    [J]. Behavior Genetics, 2006, 36 : 301 - 308
  • [6] CARBONIC-ANHYDRASE ISOZYME-IV AND ISOZYME-II IN URINARY MEMBRANES FROM CARBONIC-ANHYDRASE II-DEFICIENT PATIENTS
    SATO, S
    ZHU, XL
    SLY, WS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) : 6073 - 6076
  • [7] OLIGODENDROCYTES EXPRESS A NORMAL PHENOTYPE IN CARBONIC-ANHYDRASE II-DEFICIENT MICE
    GHANDOUR, MS
    SKOFF, RP
    VENTA, PJ
    TASHIAN, RE
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1989, 23 (02) : 180 - 190
  • [8] Altered circadian period of locomotor activity in carbonic anhydrase II-deficient mice
    Hofstetter, JR
    Gifford, KL
    Trofatter, JA
    Mayeda, AR
    [J]. BIOLOGICAL RHYTHM RESEARCH, 1999, 30 (05) : 517 - 528
  • [9] Postnatal disappearance of type A intercalated cells in carbonic anhydrase II-deficient mice
    L. P. Brion
    C. Suarez
    P. Saenger
    [J]. Pediatric Nephrology, 2001, 16 : 477 - 481
  • [10] Postnatal disappearance of type A intercalated cells in carbonic anhydrase II-deficient mice
    Brion, LP
    Suarez, C
    Saenger, P
    [J]. PEDIATRIC NEPHROLOGY, 2001, 16 (06) : 477 - 481
12345