Acute and continuation therapy in unipolar depression: observations from the run-in phase of a maintenance trial

被引：3

作者：

Rasmussen, N. A. ^{[2
]}

Andersen, P. M. ^{[2
]}

Licht, R. W. ^{[2
]}

Klaening, U. ^{[2
]}

Egander, A. ^{[2
]}

Abildgaard, W. ^{[2
]}

Richelsen, B. ^{[2
]}

Stadil, B. ^{[2
]}

Clemmensen, K. ^{[2
]}

Reiner, M. ^{[2
]}

Vestergaard, P. ^{[2
]}

Hausmann, G. ^{[2
]}

Kristensen, J. ^{[2
]}

Molgaard, K. ^{[2
]}

Malling, B. ^{[2
]}

Jensen, C. Z. ^{[2
]}

Olsen, M. ^{[3
]}

Egersgard, J. ^{[3
]}

Stage, K. B. ^{[3
]}

Christoffersen, J. ^{[3
]}

Bendsen, B. B. ^{[4
]}

Larsen, J. K. ^{[4
]}

Waetjen, I. ^{[4
]}

Holgersen, B. ^{[5
]}

Jensen, B. M. ^{[5
]}

Christensen, M. B. ^{[5
]}

Andersson, J. E. ^{[5
]}

Wedervang-Jensen, T. ^{[6
]}

Clemmensen, P. ^{[6
]}

Kayser, C. ^{[6
]}

Bock, C. ^{[6
]}

Andersen, J. ^{[7
]}

Nalders, K. ^{[7
]}

Frederiksen, K. ^{[7
]}

Andersen, M. ^{[7
]}

Christensen, E. M. ^{[8
]}

Johansen, A. M. ^{[8
]}

Martiny, K. ^{[8
]}

Borup, H. ^{[9
]}

Thomsen, I. S. ^{[9
]}

Matzen, P. ^{[9
]}

Kragh-Sorensen, P. ^{[3
]}

Bech, P. ^{[8
]}

Gram, L. F. ^{[1
]}

机构：

[1] Univ So Denmark, IST, Dept Clin Pharmacol, DK-5000 Odense C, Denmark

[2] Psychiat Univ Hosp, Aarhus, Denmark

[3] Univ So Denmark, Dept Psychiat, DK-5000 Odense C, Denmark

[4] Frederiksberg Univ Hosp, Dept Psychiat, Copenhagen, Denmark

[5] Bispebjerg Hosp, Dept Psychiat, DK-2400 Copenhagen, Denmark

[6] Gentofte Univ Hosp, Dept Psychiat, Copenhagen, Denmark

[7] Cty Hosp, Dept Psychiat, Vordingborg, Denmark

[8] Hillerod Gen Hosp, Dept Psychiat, Hillerod, Denmark

[9] Aarhus Univ Hosp, Aalborg Psychiat Hosp, Odense, Denmark

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2008年 / 118卷 / 02期

关键词：

major depressive disorder; antidepressant agents; psychotropic drugs; treatment outcome;

D O I：

10.1111/j.1600-0447.2008.01182.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The aim of the study was to analyze treatments and outcome in depressed patients. Method: Patients with recurrent depressive disorder (n = 289), recruited for a prophylaxis study, were followed up in hospital settings for 6 months with diagnostic and depression ratings at baseline and monthly depression ratings. Data on psychotropic drugs were retrieved from hospital case records. Independent associations between baseline, treatment and outcome variables were examined by logistic regression models. Results: Depressive symptoms subsided gradually. After 6 months, 21% had dropped out, 43% were rated as remitted (HAM-D-17 < 8) and 8% had not responded (HAM-D-17 > 15). Patients once remitted rarely relapsed (< 5%). All patients received antidepressant drugs, half of them more than one (2-4) as well as other psychotropic drugs. Patients responding poorly received more frequently multiple antidepressants, tricyclic antidepressants, hypnosedatives, lithium and/or antipsychotics. Conclusions: The 6-month outcome was generally poor. Choice of treatment appeared at least partly to be determined by the therapeutic outcome.

引用

页码：123 / 129

页数：7

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