Biochemical Characterization of GS-4059 As a Potent and Selective Covalent Irreversible Inhibitor of Bruton's Tyrosine Kinase

被引:3
|
作者
Liclican, Albert [1 ]
Xing, Weimei [1 ]
Serafini, Loredana [1 ]
Wang, Ting [1 ]
Brendza, Kathy [1 ]
Lutz, Justin [1 ]
Ray, Adrian S. [1 ]
Schultz, Brian [1 ]
Sakowicz, Roman [1 ]
Feng, Joy Y. [1 ]
机构
[1] Gilead Sci Inc, Foster City, CA USA
关键词
D O I
10.1182/blood.V128.22.1594.1594
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1594
引用
收藏
页数:5
相关论文
共 50 条
  • [1] Bruton tyrosine kinase inhibitor ONO/GS-4059: from bench to bedside
    Wu, Jingjing
    Zhang, Mingzhi
    Liu, Delong
    [J]. ONCOTARGET, 2017, 8 (04) : 7201 - 7207
  • [2] A Pharmacokinetic-Pharmacodynamic (PKPD) Model Describing Irreversible Inhibition of Bruton's Tyrosine Kinase by GS-4059
    Lutz, Justin D.
    Nelson, Cara
    Yu, Helen
    Liclican, Albert
    Feng, Joy
    Billin, Andrew
    Schultz, Brian E.
    Bresnik, Mark
    Mathias, Anita
    [J]. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2016, 43 : S63 - S64
  • [3] Long-term follow-up of patients with CLL treated with the selective Bruton's tyrosine kinase inhibitor ONO/GS-4059
    Walter, Harriet S.
    Jayne, Sandrine
    Rule, Simon A.
    Cartron, Guillaume
    Morschhauser, Franck
    Macip, Salvador
    Karlin, Lionel
    Jones, Ceri
    Herbaux, Charles
    Quittet, Philippe
    Shah, Nimish
    Hutchinson, Claire V.
    Fegan, Christopher
    Yang, Yingsi
    Mitra, Siddhartha
    Salles, Gilles
    Dyer, Martin J. S.
    [J]. BLOOD, 2017, 129 (20) : 2808 - 2810
  • [4] Responses to the Selective Bruton's Tyrosine Kinase (BTK) Inhibitor Tirabrutinib (ONO/GS-4059) in Diffuse Large B-cell Lymphoma Cell Lines
    Kozaki, Ryohei
    Vogler, Meike
    Walter, Harriet S.
    Jayne, Sandrine
    Dinsdale, David
    Siebert, Reiner
    Dyer, Martin J. S.
    Yoshizawa, Toshio
    [J]. CANCERS, 2018, 10 (04)
  • [5] Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase
    Tichenor, Mark S.
    Wiener, John J. M.
    Rao, Navin L.
    Bacani, Genesis M.
    Wei, Jianmei
    Deckhut, Charlotte Pooley
    Barbay, J. Kent
    Kreutter, Kevin D.
    Chang, Leon
    Clancy, Kathleen W.
    Murrey, Heather E.
    Wang, Weixue
    Ahn, Kay
    Huber, Michael
    Rex, Elizabeth
    Coe, Kevin J.
    Wu, Jiejun
    Rui, Haopeng
    Sepassi, Kia
    Gaudiano, Marcello
    Bekkers, Mariette
    Cornelissen, Ivo
    Packman, Kathryn
    Seierstad, Mark
    Xiouras, Christos
    Bembenek, Scott D.
    Alexander, Richard
    Milligan, Cynthia
    Balasubramanian, Sriram
    Lebsack, Alec D.
    Venable, Jennifer D.
    Philippar, Ulrike
    Edwards, James P.
    Hirst, Gavin
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (21) : 14326 - 14336
  • [6] HZ-A-005, a potent, selective, and covalent Bruton's tyrosine kinase inhibitor in preclinical development
    Huang, Wenhai
    Wang, Shu
    Zhang, Zhimin
    Zhang, Chixiao
    Zeng, Shenxin
    Liang, Meihao
    Shen, Zhengrong
    Liu, Xingguo
    [J]. BIOORGANIC CHEMISTRY, 2020, 105
  • [7] Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase
    Angst, Daniela
    Gessier, Francois
    Janser, Philipp
    Vulpetti, Anna
    Walchli, Rudolf
    Beerli, Christian
    Littlewood-Evans, Amanda
    Dawson, Janet
    Nuesslein-Hildesheim, Barbara
    Wieczorek, Grazyna
    Gutmann, Sascha
    Scheufler, Clemens
    Hinniger, Alexandra
    Zimmerlin, Alfred
    Funhoff, Enrico G.
    Pulz, Robert
    Cenni, Bruno
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (10) : 5102 - 5118
  • [8] Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase
    Guo, Yunhang
    Liu, Ye
    Hu, Nan
    Yu, Desheng
    Zhou, Changyou
    Shi, Gongyin
    Zhang, Bo
    Wei, Min
    Liu, Junhua
    Luo, Lusong
    Tang, Zhiyu
    Song, Huipeng
    Guo, Yin
    Liu, Xuesong
    Su, Dan
    Zhang, Shuo
    Song, Xiaomin
    Zhou, Xing
    Hong, Yuan
    Chen, Shuaishuai
    Cheng, Zhenzhen
    Young, Steve
    Wei, Qiang
    Wang, Haisheng
    Wang, Qiuwen
    Lv, Lei
    Wang, Fan
    Xu, Haipeng
    Sun, Hanzi
    Xing, Haimei
    Li, Na
    Zhang, Wei
    Wang, Zhongbo
    Liu, Guodong
    Sun, Zhijian
    Zhou, Dongping
    Li, Wei
    Liu, Libin
    Wang, Lai
    Wang, Zhiwei
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (17) : 7923 - 7940
  • [9] Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity
    Tichenor, Mark S.
    Wiener, John J. M.
    Rao, Navin L.
    Deckhut, Charlotte Pooley
    Barbay, J. Kent
    Kreutter, Kevin D.
    Bacani, Genesis M.
    Wei, Jianmei
    Chang, Leon
    Murrey, Heather E.
    Wang, Weixue
    Ahn, Kay
    Huber, Michael
    Rex, Elizabeth
    Coe, Kevin J.
    Wu, JieJun
    Seierstad, Mark
    Bembenek, Scott D.
    Leonard, Kristi A.
    Lebsack, Alec D.
    Venable, Jennifer D.
    Edwards, James P.
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2021, 12 (05): : 782 - 790
  • [10] Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
    Pan, Zhengying
    Scheerens, Heleen
    Li, Shyr-Jiann
    Schultz, Brian E.
    Sprengeler, Paul A.
    Burrill, L. Chuck
    Mendonca, Rohan V.
    Sweeney, Michael D.
    Scott, Keana C. K.
    Grothaus, Paul G.
    Jeffery, Douglas A.
    Spoerke, Jill M.
    Honigberg, Lee A.
    Young, Peter R.
    Dalrymple, Stacie A.
    Palmer, James T.
    [J]. CHEMMEDCHEM, 2007, 2 (01) : 58 - 61