Hematopoietic Stem Cell Transplant for Mycosis Fungoides and Sezary Syndrome

被引：25
|
作者：
Virmani, Pooja [1 ]
Zain, Jasmine [2 ]
Rosen, Steven T. [2 ]
Myskowski, Patricia L. [1 ]
Querfeld, Christiane [2 ,3 ,4 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Med, Dermatol Serv, New York, NY 10022 USA
[2] City Hope Comprehens Canc Ctr, Dept Hematol Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
[3] City Hope Comprehens Canc Ctr, Dept Pathol, Duarte, CA 91010 USA
[4] Mem Sloan Kettering Canc Ctr, New York, NY 10022 USA
来源：
DERMATOLOGIC CLINICS | 2015年 / 33卷 / 04期
关键词：
Cutaneous T-cell lymphoma; Mycosis fungoides; Sezary syndrome; Autologous hematopoietic stem cell transplant; Allogeneic hematopoietic stem cell transplant; Myeloablative; Reduced-intensity conditioning; BONE-MARROW-TRANSPLANTATION; CUTANEOUS-LYMPHOMAS; INTERNATIONAL-SOCIETY; PROGNOSTIC-FACTORS; WORKING PARTY; BLOOD; GRAFT; DISEASE; CLASSIFICATION; ORGANIZATION;
D O I：
10.1016/j.det.2015.05.014
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Mycosis fungoides (MF) and Sezary syndrome (SS) are common types of primary cutaneous T-cell lymphoma. Early-stage MF has a favorable prognosis and responds well to skin-directed regimens. Patients with advanced-stage MF, transformed MF, and SS are treated with combined systemic and skin-directed therapies. However, the disease is incurable with standard regimens, and frequent relapses are common. Owing to the lack of improvement in overall survival with standard regimens, hematopoietic stem cell transplant (HSCT) has been explored as a potential curative option. This article reviews the role of HSCT in MF/SS and discusses data regarding conditioning regimens, treatment-related complications, and outcomes.
引用
收藏
页码：807 / +
页数：13
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