Novel mutants of human butyrylcholinesterase as therapeutic enzymes in metabolizing cocaine, norcocaine, and cocaethylene

被引:0
|
作者
Zhan, Max [1 ]
Hou, Shurong [1 ]
Zhan, Chang-Guo [1 ]
Zheng, Fang [1 ]
机构
[1] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
285-MEDI
引用
收藏
页数:1
相关论文
共 20 条
  • [1] Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine
    Zhan, Max
    Hou, Shurong
    Zhan, Chang-Guo
    Zheng, Fang
    BIOCHEMICAL JOURNAL, 2014, 457 : 197 - 206
  • [2] Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene
    Hou, Shurong
    Zhan, Max
    Zheng, Xirong
    Zhan, Chang-Guo
    Zheng, Fang
    BIOCHEMICAL JOURNAL, 2014, 460 : 447 - 457
  • [3] Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine
    Xue, Liu
    Hou, Shurong
    Tong, Min
    Fang, Lei
    Chen, Xiabin
    Jin, Zhenyu
    Tai, Hsin-Hsiung
    Zheng, Fang
    Zhan, Chang-Guo
    BIOCHEMICAL JOURNAL, 2013, 453 : 447 - 454
  • [4] Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants
    Hamza, A
    Cho, H
    Tai, HH
    Zhan, CG
    JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (10): : 4776 - 4782
  • [5] Development of a method for the determination of cocaine, cocaethylene and norcocaine in human breast milk using liquid phase microextraction and gas chromatography-mass spectrometry
    Silveira, Gabriela de Oliveira
    Belitsky, Iris Tikkanen
    Loddi, Silvana
    Rodrigues de Oliveira, Carolina Dizioli
    Zucoloto, Alexandre Dias
    Gimenez Fruchtengarten, Ligia Veras
    Yonamine, Mauricio
    FORENSIC SCIENCE INTERNATIONAL, 2016, 265 : 22 - 28
  • [6] Determination of cocaine, benzoylecgonine, cocaethylene and norcocaine in human hair using solid-phase extraction and liquid chromatography with tandem mass spectrometric detection
    Moore, Christine
    Coulter, Cynthia
    Crompton, Katherine
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 859 (02): : 208 - 212
  • [7] Quantitation of cocaine, benzoylecgonine, cocaethylene, methylecgonine, and norcocaine in human hair by positive ion chemical ionization (PICI) gas chromatography-tandem mass spectrometry
    Bourland, JA
    Hayes, EF
    Kelly, RC
    Sweeney, SA
    Hatab, MM
    JOURNAL OF ANALYTICAL TOXICOLOGY, 2000, 24 (07) : 489 - 495
  • [8] Design, Preparation, and Characterization of High-Activity Mutants of Human Butyrylcholinesterase Specific for Detoxification of Cocaine
    Xue, Liu
    Ko, Mei-Chuan
    Tong, Min
    Yang, Wenchao
    Hou, Shurong
    Fang, Lei
    Liu, Junjun
    Zheng, Fang
    Woods, James H.
    Tai, Hsin-Hsiung
    Zhan, Chang-Guo
    MOLECULAR PHARMACOLOGY, 2011, 79 (02) : 290 - 297
  • [9] Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants
    Pan, Yongmei
    Gao, Daquan
    Yang, Wenchao
    Cho, Hoon
    Zhan, Chang-Guo
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (44) : 13537 - 13543
  • [10] Free Energy Perturbation Simulation on Transition States and High-Activity Mutants of Human Butyrylcholinesterase for (-)-Cocaine Hydrolysis
    Yang, Wenchao
    Pan, Yongmei
    Fang, Lei
    Gao, Daquan
    Zheng, Fang
    Zhan, Chang-Guo
    JOURNAL OF PHYSICAL CHEMISTRY B, 2010, 114 (33): : 10889 - 10896