Tissue inhibitors of matrix metalloproteinases in cancer

被引：68
|
作者：
Blavier, L
Henriet, P
Imren, S
DeClerck, YA
机构：
[1] Childrens Hosp Los Angeles, Dept Pediat, Div Hematol Oncol, Los Angeles, CA 90027 USA
[2] Childrens Hosp Los Angeles, Dept Biochem & Mol Biol, Los Angeles, CA 90027 USA
[3] Univ So Calif, Los Angeles, CA USA
来源：
INHIBITION OF MATRIX METALLOPROTEINASES: THERAPEUTIC APPLICATIONS | 1999年 / 878卷
关键词：
D O I：
10.1111/j.1749-6632.1999.tb07677.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in the homeostasis of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases (MMPs). Some TIMPs have a second function as well, unrelated to their antiMMP activity, which affects cell proliferation and survival. The role of these inhibitors in cancer has been the subject of extensive investigations that have examined their biological activity in tumor growth, invasion, metastasis and angiogenesis, as well as their potential use in the diagnosis and treatment of human cancer.
引用
收藏
页码：108 / 119
页数：12
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