Synthesis of trans-vaccenic acid and cis-9-trans-11-conjugated linoleic acid

被引：22
|
作者：
Duffy, PE
Quinn, SM
Roche, HM
Evans, P [1 ]
机构：
[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland
[2] Inst Mol Med, Dept Clin Med, Nutrigenom Res Grp, St James Hosp, Dublin 8, Ireland
来源：
TETRAHEDRON | 2006年 / 62卷 / 20期
关键词：
D O I：
10.1016/j.tet.2006.03.006
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation of the monounsaturated fatty acid, trans-vaccenic acid 4 (TVA), using both Wittig and one-pot Julia-Kocienski olefination protocol, was achieved in good yield. Similarly a Wittig approach was employed for the stereoselective synthesis of cis-9-trans-11-conjugated linoleic acid 2 from trans-2-nonenal and (8-carboxyoctyl)triphenylphosphonium bromide 12. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4838 / 4843
页数：6
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