Synthesis and Evaluation of Pyrido[2,3-d]pyrimidine and 1,8-Naphthyridine Derivatives as Potential Antitumor Agents

被引：28
|
作者：
Behalo, Mohamed S. [1 ]
Mele, Giuseppe [2 ]
机构：
[1] Benha Univ, Fac Sci, Dept Chem, Banha 13518, Egypt
[2] Univ Salento, Dept Engn Innovat, Lecce, Italy
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 01期
关键词：
3-COMPONENT SYNTHESIS; ONE-POT; INHIBITORS; ANTIBACTERIAL; DISCOVERY;
D O I：
10.1002/jhet.2581
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New series of pyrido[2,3-d]pyrimidine and 1,8-naphthyridine derivatives were synthesized from 2-amino-6( phenoxathiin-2-yl)-4-(thiophene-2-yl) nicotinonitrile as starting material, and their structures were characterized on the basis of the spectral data. Most of the synthesized compounds were evaluated for their cytotoxic activity against two cancer cell lines, namely, breast cancer Michigan Cancer Foundation-7 (MCF-7) and prostate cancer human prostatic carcinoma cell line (PC-3) using MTT assay. Some of these compounds showed potent cytotoxic effect concluded from their IC50 values.
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页码：295 / 300
页数：6
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