Developmental regulation of alpha-tubulin mRNAs during the differentiation of cultured cerebellar granule cells

被引：5
|
作者：
Przyborski, SA [1 ]
CambrayDeakin, MA [1 ]
机构：
[1] UNIV SHEFFIELD,DEPT BIOMED SCI,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND
来源：
MOLECULAR BRAIN RESEARCH | 1996年 / 36卷 / 01期
关键词：
alpha-tubulin; gene isotype; cerebellum; granule cell; neuritogenesis; neuronal culture; in situ hybridization;
D O I：
10.1016/0169-328X(95)00292-Z
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
T alpha 1 and T26 alpha-tubulin mRNA expression was examined during the differentiation of rat cerebellar granule cells in vitro and in situ. High levels of T alpha 1 transcript correlated with neurons extending processes and hence may implicate T alpha 1 with neuritogenesis. In comparison, T26 labeling was much less prominent, appeared more constitutive and was possibly associated with cell proliferation. Such profiles indicate that the different isotypes play different roles in the assembly and function of microtubules during neuronal differentiation.
引用
收藏
页码：179 / 183
页数：5
相关论文
共 50 条
  • [1] DEVELOPMENTAL REGULATION OF DROSOPHILA ALPHA-TUBULIN GENES
    KALFAYAN, L
    WENSINK, PC
    [J]. CELL, 1982, 29 (01) : 91 - 98
  • [2] Developmental regulation of expression of GABA(A) receptor alpha 1 and alpha 6 subunits in cultured rat cerebellar granule cells
    Thompson, CL
    Pollard, S
    Stephenson, FA
    [J]. NEUROPHARMACOLOGY, 1996, 35 (9-10) : 1337 - 1346
  • [3] COMPLEX REGULATION AND FUNCTIONAL VERSATILITY OF MAMMALIAN ALPHA-TUBULIN AND BETA-TUBULIN ISOTYPES DURING THE DIFFERENTIATION OF TESTIS AND MUSCLE-CELLS
    LEWIS, SA
    COWAN, NJ
    [J]. JOURNAL OF CELL BIOLOGY, 1988, 106 (06): : 2023 - 2033
  • [4] DEVELOPMENTAL REGULATION OF POLYGLUTAMYLATED ALPHA-TUBULIN AND BETA-TUBULIN IN MOUSE-BRAIN NEURONS
    AUDEBERT, S
    KOULAKOFF, A
    BERWALDNETTER, Y
    GROS, F
    DENOULET, P
    EDDE, B
    [J]. JOURNAL OF CELL SCIENCE, 1994, 107 : 2313 - 2322
  • [5] DEVELOPMENTAL EXPRESSION OF SPECTRIN ALPHA AND BETA SUBUNITS IN RAT CEREBELLUM AND IN CULTURED CEREBELLAR GRANULE CELLS
    CECCARINI, M
    ROSA, G
    GIOVANNINI, C
    DISTASI, AMM
    PETRUCCI, TC
    [J]. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 1991, 12 (05) : 492 - 492
  • [6] IMMUNOCYTOCHEMICAL DEMONSTRATION OF ALPHA-TUBULIN MODIFICATION DURING AXONAL MATURATION IN THE CEREBELLAR CORTEX
    CUMMING, R
    BURGOYNE, RD
    LYTTON, NA
    [J]. JOURNAL OF CELL BIOLOGY, 1984, 98 (01): : 347 - 351
  • [7] ACETYLATION OF ALPHA-TUBULIN (ALPHA-TUB) IN CULTURED NEURONS
    BLACK, MM
    KEYSER, P
    [J]. JOURNAL OF CELL BIOLOGY, 1986, 103 (05): : A128 - A128
  • [8] ACETYLATION OF ALPHA-TUBULIN IN CULTURED NEURONS AND THE INDUCTION OF ALPHA-TUBULIN ACETYLATION IN PC12-CELLS BY TREATMENT WITH NERVE GROWTH-FACTOR
    BLACK, MM
    KEYSER, P
    [J]. JOURNAL OF NEUROSCIENCE, 1987, 7 (06): : 1833 - 1842
  • [9] IMMUNOFLUORESCENCE DISTRIBUTION OF ALPHA-TUBULIN, BETA-TUBULIN AND MICROTUBULE-ASSOCIATED PROTEIN-2 DURING INVITRO MATURATION OF CEREBELLAR GRANULE CELL NEURONS
    CUMMING, R
    BURGOYNE, RD
    LYTTON, NA
    [J]. NEUROSCIENCE, 1984, 12 (03) : 775 - 782
  • [10] REGULATION OF GLUTAMATE RECEPTORS IN CULTURED CEREBELLAR GRANULE CELLS (GCS)
    BALAZS, R
    ARONICA, E
    RESINK, A
    HACK, N
    CONDORELLI, DF
    DELLALBANI, P
    KUMAR, KN
    MICHAELIS, E
    [J]. JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S268 - S268
12345