Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine Hfe-haemochromatosis

被引：19

作者：

Gutierrez, Lucia ^{[1
,2
]}

Spasic, Maja Vujic ^{[3
,4
]}

Muckenthaler, Martina U. ^{[3
,4
]}

Lazaro, Francisco J. ^{[5
]}

机构：

[1] Univ Western Australia, Sch Phys, Crawley, WA 6009, Australia

[2] ICMM CSIC, Madrid 28049, Spain

[3] Univ Heidelberg Hosp, Dept Hematol Immunol & Oncol, D-69120 Heidelberg, Germany

[4] Univ Heidelberg Hosp, Mol Med Partnership Unit, D-69120 Heidelberg, Germany

[5] Univ Zaragoza, Dept Ciencia & Tecnol Mat & Fluidos, Zaragoza 50018, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2012年 / 1822卷 / 07期

关键词：

Ferritin; Iron; AC susceptibility; Paramagnetic; Hfe; Haemochromatosis; LIVER; TISSUES; OXYHEMOGLOBIN; HEPCIDIN; OVERLOAD; DEPOSITS; DEXTRAN; FORM;

D O I：

10.1016/j.bbadis.2012.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantitative analysis of the temperature dependent AC magnetic susceptibility of freeze-dried mouse tissues from an Hfe hereditary haemochromatosis disease model indicates that iron predominantly appears biomineralised, like in the ferritin cores, in the liver, the spleen and duodenum. The distribution of the amount of ferritin-like iron between genders and genotypes coincides with that of elemental iron and nonheme iron. Importantly, the so-called paramagnetic iron, a quantity also determined from the magnetic data and indicative of nonmineralised iron forms, appears only marginally increased when iron overload takes place. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：1147 / 1153

页数：7