Cu(OAc)2-Catalyzed Tandem Blaise/Pinner-Type Reaction for One-Pot Synthesis of Pyrimidin-4-ones

被引：28
|
作者：
Chun, Yu Sung [1 ]
Kim, Ju Hyun [1 ]
Choi, Suh Young [1 ]
Ko, Young Ok [1 ]
Lee, Sang-gi [1 ]
机构：
[1] Ewha Womans Univ, Dept Chem & Nano Sci BK21, Seoul 120750, South Korea
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 24期
关键词：
BLAISE REACTION INTERMEDIATE; EFFICIENT SYNTHESIS; ENAMINOESTERS; ACYLATION; NITRILES; ESTERS;
D O I：
10.1021/ol303153g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)(2) to afford pyrimidin-4-ones.
引用
收藏
页码：6358 / 6361
页数：4
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