The anticancer effects of Cucurbitacin I inhibited cell growth of human non-small cell lung cancer through PI3K/AKT/p70S6K pathway

被引：18
|
作者：
Zhu, Xueqiang [1 ]
Huang, Hui [1 ]
Zhang, Jun [2 ]
Liu, Hao [1 ]
Ao, Rui [1 ]
Xiao, Ming [1 ]
Wu, Yuelei [3 ]
机构：
[1] Sichuan Prov Peoples Hosp, Ctr Oncol, Chengdu 610072, Sichuan, Peoples R China
[2] Third Peoples Hosp Chengdu, Dept Oncol, Chengdu 610031, Sichuan, Peoples R China
[3] Chengdu First Peoples Hosp, Dept Gerontol, 18 Wanxiang North Rd, Chengdu 610041, Sichuan, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2018年 / 17卷 / 02期
关键词：
Cucurbitacin I; non-small cell lung cancer; phosphatidylinositol-4,5-bisphosphate 3-kinase; AKT; p70S6K; PLATINUM-BASED CHEMOTHERAPY; SIGNALING PATHWAY; PI3K/AKT/MTOR PATHWAY; MAINTENANCE THERAPY; 1ST-LINE TREATMENT; KINASE; ACTIVATION; TRIAL; CHEMOSENSITIVITY; PROGRESSION;
D O I：
10.3892/mmr.2017.8141
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The present study aimed to identify potential anticancer effects of Cucurbitacin I regulators on cell growth of human non-small cell lung cancer (NSCLC) and to explore their mechanism. The results indicated that the anticancer effects of Cucurbitacin I markedly attenuated cell proliferation, and induced apoptosis in NSCLC. Furthermore, Cucurbitacin I suppressed phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), phosphorylation (p)-AKT and p-p70S6K pathway in NSCLC. Then, (PI3K) inhibitor increased anticancer effects of Cucurbitacin I on NSCLC. In conclusion, the present results indicated that Cucurbitacin I inhibited cell growth of human NSCLC through PI3K/AKT/p70S6K signaling pathway.
引用
收藏
页码：2750 / 2756
页数：7
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