Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis

被引：15
|
作者：
Kirkpatrick, WR
Vallor, AC
McAtee, RK
Ryder, NS
Fothergill, AW
Rinaldi, MG
Patterson, TF
机构：
[1] Univ Texas, Hlth Sci Ctr, Dept Med, Div Infect Dis, San Antonio, TX 78229 USA
[2] Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78229 USA
[3] S Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX 78284 USA
[4] Novartis Inst Biomed Res Inc, Concord, MA 01742 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 11期
关键词：
D O I：
10.1128/AAC.49.11.4751-4753.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.
引用
收藏
页码：4751 / 4753
页数：3
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