Cerebrospinal Fluid from Alzheimer's Disease Patients Contains Fungal Proteins and DNA

被引：29

作者：

Alonso, Ruth ^{[1
]}

Pisa, Diana ^{[1
]}

Rabano, Alberto ^{[2
]}

Rodal, Izaskun ^{[2
]}

Carrasco, Luis ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain

[2] Inst Salud Carlos III, Fdn CIEN, Unidad Invest Proyecto Alzheimer, Dept Neuropathol & Tissue Bank, Madrid, Spain

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 47卷 / 04期

关键词：

Cerebrospinal fluid biomarker; fungal DNA; fungal infection; neurodegenerative disease; protein biomarker; HERPES-SIMPLEX-VIRUS; AMYOTROPHIC-LATERAL-SCLEROSIS; DETECT CHLAMYDIA-PNEUMONIAE; INFECTIOUS AGENTS; BRAIN; BIOMARKERS; TYPE-1; PROGRESSION; FAILURE; TAU;

D O I：

10.3233/JAD-150382

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The identification of biomarkers for Alzheimer's disease is important for patient management and to assess the effectiveness of clinical intervention. Cerebrospinal fluid (CSF) biomarkers constitute a powerful tool for diagnosis and monitoring disease progression. We have analyzed the presence of fungal proteins and DNA in CSF from AD patients. Our findings reveal that fungal proteins can be detected in CSF with different anti-fungal antibodies using a slot-blot assay. Additionally, amplification of fungal DNA by PCR followed by sequencing distinguished several fungal species. The possibility that these fungal macromolecules could represent AD biomarkers is discussed.

引用

页码：873 / 876

页数：4

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