Synthesis of achiral and chiral N-protected γ-amino-β-ketones and β-ketoesters

被引：7

作者：

Katritzky, Alan R. ^{[1
]}

Wang, Zuoquan ^{[1
]}

Hall, C. Dennis ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

ARKIVOC | 2008年

关键词：

Benzotriazole; achiral; chiral; protected; ketones; ketoesters;

D O I：

10.3998/ark.5550190.0009.a04

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel chiral N-carbamate-protected gamma-amino-beta-ketones 3a-c and the known N-carbamate-protected nitroketone 3d were prepared from the corresponding 1-(N-protected alpha-aminoacyl) benzotriazoles 1 by reaction with nucleophiles 2a-d in the presence of bases under mild conditions. Similarly achiral and chiral N-protected gamma-amino-beta-ketoesters 3e-1 were prepared by reaction with acetoacetates in the presence of sodium hydride.

引用

页码：26 / 36

页数：11

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