Common chromosomal fragile sites and cancer: Focus on FRA16D

被引：60
|
作者：
O'Keefe, LV [1 ]
Richards, RI [1 ]
机构：
[1] Univ Adelaide, Sch Mol & Biomed Sci, ARC Special Res Ctr Mol Genet Dev, NHMRC,Res Network Genes & Environm Dev, Adelaide, SA 5005, Australia
来源：
CANCER LETTERS | 2006年 / 232卷 / 01期
关键词：
common chromosomal fragile site; in vitro fragility/in vivo instability; protective gene function;
D O I：
10.1016/j.canlet.2005.07.041
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A growing body of experimental evidence supports the view that certain human chromosomal fragile sites have roles to play in cancer. The principle lines of evidence are at the level of mutation mechanism and gene function. Most research in this area has previously focussed on the FRA3B common fragile site and the FHIT gene that spans this site. Here we review recent progress in characterising the second most readily observed common fragile site, FRA16D, and the WWOX gene that spans it. Comparative analyses of FRA3B/FHIT and FRA16D/WWOX reveal some striking similarities suggesting that these sites and their associated genes may play a part in a normal protective response of cells to environmental stress. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：37 / 47
页数：11
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