The interplay between structure-based design and combinatorial chemistry

被引：15

作者：

Rupasinghe, Chamila N. ^{[1
]}

Spaller, Mark R. ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2006年 / 10卷 / 03期

关键词：

D O I：

10.1016/j.cbpa.2006.03.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two most lauded drug design approaches from the past century - structure-based design and combinatorial chemistry - are increasingly experiencing integration, whereby the three-dimensional coordinates of a receptor supports the development of combinatorial-based ligand design. A selective polling of the recent literature demonstrates that this can be actualized in many ways.

引用

页码：188 / 193

页数：6

共 50 条

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