Genetic and Environmental Influences on Language Ability in Older Adults: Findings from the Older Australian Twins Study

被引：5
|
作者：
Lee, T. [1 ,2 ,7 ]
Thalamuthu, A. [1 ]
Henry, J. D. [3 ]
Trollor, J. N. [1 ,4 ]
Ames, D. [6 ]
Wright, M. J. [3 ,5 ]
Sachdev, P. S. [1 ,2 ]
机构：
[1] Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia
[2] Prince Wales Hosp, Neuropsychiat Inst, Randwick, NSW, Australia
[3] Univ Queensland, Sch Psychol, St Lucia, Qld, Australia
[4] Univ New South Wales, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia
[5] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia
[6] Univ Melbourne, Acad Unit Psychiat Old Age, St Georges Hosp, Melbourne, Vic, Australia
[7] UNSW Sydney, Ctr Hlth Brain Ageing CHeBA, NPI Euroa Ctr, Prince Wales Hosp, Barker St, Randwick, NSW 2031, Australia
来源：
BEHAVIOR GENETICS | 2018年 / 48卷 / 03期
基金：
英国医学研究理事会;
关键词：
Genetic; Heritability; Twins; Aging; Language ability; VERBAL FLUENCY PERFORMANCE; COGNITIVE-ABILITIES; SEX-DIFFERENCES; HERITABILITY; METAANALYSIS; DEMENTIA;
D O I：
10.1007/s10519-018-9897-z
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
We used a sub-sample from the Older Australian Twins Study to estimate the heritability of performance on three tests of language ability: Boston Naming Test (BNT), Letter/Phonemic Fluency (FAS) and Category/Semantic Fluency (CFT) Tests. After adjusting for age, sex, education, mood, and global cognition (GC), heritability estimates obtained for the three tests were 0.35, 0.59, and 0.20, respectively. Multivariate analyses showed that the genetic correlation were high for BNT and CFT (0.61), but low for BNT and FAS (0.17), and for FAS and CFT (0.28). Genetic modelling with Cholesky decomposition indicated that the covariation between the three measures could be explained by a common genetic factor. Environmental correlations between the language ability measures were low, and there were considerable specific environmental influences for each measure. Future longitudinal studies with language performance and neuroimaging data can further our understanding of genetic and environmental factors involved in the process of cognitive aging.
引用
收藏
页码：187 / 197
页数：11
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