Lifetime total physical activity and prostate cancer risk: a population-based case-control study in Sweden

被引:28
|
作者
Wiklund, Fredrik [1 ]
Lageros, Ylva Trolle [2 ]
Chang, Ellen [3 ,4 ]
Balter, Katarina [1 ]
Johansson, Jan-Erik [5 ]
Adami, Hans-Olov [1 ,6 ]
Gronberg, Henrik [1 ]
机构
[1] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Dept Med, Clin Epidemiol Unit, S-17176 Stockholm, Sweden
[3] No Calif Canc Ctr, Fremont, CA 94538 USA
[4] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA 94305 USA
[5] Orebro Univ Hosp, Dept Urol, S-70116 Orebro, Sweden
[6] Harvard Univ, Dept Epidemiol, Boston, MA 02115 USA
关键词
Case-control studies; Epidemiology; Exercise; Leisure activities; Prostatic neoplasms; Risk;
D O I
10.1007/s10654-008-9294-7
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The etiologic role of physical activity in prostate cancer development is unclear. We assessed the association between lifetime total physical activity and prostate cancer risk in a Swedish population-based case-control study comprising 1,449 incident prostate cancer cases and 1,118 unaffected population controls. Information regarding physical activity was obtained via a self-administered questionnaire assessing occupational, household, and recreational activity separately at various ages throughout an individual's lifetime. Clinical data (TNM-classification, Gleason sum and PSA) was obtained from linkage to the National Prostate Cancer Registry. Overall, we observed no association between lifetime total physical activity and prostate cancer risk (odds ratio [OR] = 1.04, 95% confidence interval [CI] = 0.77-1.41 for a parts per thousand yen49.7 vs. < 41.9 metabolic equivalent-hours per day). There was a significantly increased risk of prostate cancer in the most active men compared with the least active men in household (OR = 1.44, 95% CI = 1.08-1.92) and recreational physical activity (OR = 1.56, 95% CI = 1.16-2.10). Comparing the most active with the least active men, total physical activity was not associated with either localized disease (OR = 0.95, 95% CI = 0.67-1.34) or advanced disease (OR = 1.19, 95% CI = 0.83-1.71). These findings do not support the hypothesis that physical activity uniformly protects against prostate cancer development.
引用
收藏
页码:739 / 746
页数:8
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