Kinetics of degradation of sulphasalazine in aqueous solution

The degradation kinetics of sulphasalazine was studied in aqueous solution at room temperature in the pH range of 3-12 with an ionic strength of 0.2 mu. The degradation rates were determined by quantitative thin layer chromatographic and spectroscopic methods. The degradation of the drug is of first order and has a maixmum stability at pH 5.7.