Schild (apparent pA2) analysis of a κ-opioid antagonist in Planaria

被引：6
|
作者：
Raffa, Robert B.
Baron, David A.
Tallarida, Ronald J.
机构：
[1] Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19140 USA
[2] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2006年 / 540卷 / 1-3期
关键词：
kappa-opioid receptor; Planaria; schild (pA(2)) analysis;
D O I：
10.1016/j.ejphar.2006.04.027
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Previous investigators have provided radiommumological and immunocytochemical evidence for an enkephalinergic (opioid) system in Planaria and described naloxone-sensitive qualitative behavioral responses to kappa-opioid receptor agonists. We report the application of Schild-analysis to the antagonism of a selective kappa agonist (U-50, 488H) by a selective kappa antagonist (nor-BNI) in a quantitative in vivo endpoint. The results provide further evidence of a kappa-opioid-like receptor in planarians. (c) 2006 Elsevier B.V. All rights reserved.
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页码：200 / 201
页数：2
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